Evidence map›Paper›PMID 38884683›Full record

ArticleOrganic & biomolecular chemistry2024

Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate.

Lin Qiu, Hao Jiang, Charles Zhou, Vijai Kumar Reddy Tangadanchu, Jinzhi Wang, Tianyu Huang, Robert J Gropler, Joel S Perlmutter, Tammie L S Benzinger, Zhude Tu

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Automated production of radiotracer [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lin QiuDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0001-8823-4132
Hao JiangDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0002-8845-4378
Charles ZhouDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.
Vijai Kumar Reddy TangadanchuDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0003-4073-5362
Jinzhi WangDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.
Tianyu HuangDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0002-5607-4901
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0002-6550-0570
Joel S PerlmutterDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0003-3263-8917
Tammie L S BenzingerDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0002-8114-0552
Zhude TuDepartment of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA. zhudetu@wustl.edu.ORCID 0000-0003-0325-835X

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
PET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
Investigate neuroinflammation in the brain of PD using S1P1 radioligandsR01NS134586 · NINDS · WASHINGTON UNIVERSITY · PI JOEL Synes PERLMUTTER, Zhude Tu · 2024 to 2026
$1.8M
NIBIB NIH HHS P41 EB025815NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS134586
6 · The paper itself

Abstract

Here we report our design and synthesis of 28 new fluorine-containing compounds as potential F-18 radiotracers for CNS imaging of sphingosine-1-phosphate receptor 1 (S1PR1), and determination of their

Indexed as

Drug DesignFluorine RadioisotopesSphingosine-1-Phosphate ReceptorsAnimalsBrainHumansMacaca mulattaMalePositron-Emission TomographyRadiopharmaceuticalsRatsReceptors, LysosphingolipidTissue DistributionFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsReceptors, LysosphingolipidSphingosine-1-Phosphate Receptors

Identifiers

PMID38884683
PMCPMC11238945

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.