Evidence map›Paper›PMID 38884597›Full record

ArticleJPEN. Journal of parenteral and enteral nutrition2024

A simple step to improve fat and energy delivery of human milk delivered via bottle-feeding pump: An experimental study.

Caitlin Irwin, Kate Beard, Louis Martin, Kok Lim Kua, Katie Huff

Abstract read
In one paragraph

Article in JPEN. Journal of parenteral and enteral nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Caitlin IrwinIndiana University School of Medicine, Division of Neonatal-Perinatal Medicine, Indianapolis, Indiana, USA.
Kate BeardRiley Hospital for Children at Indiana University Health, Department of Pharmacy and Clinical Nutrition, Indianapolis, Indiana, USA.ORCID 0009-0004-2117-1383
Louis MartinIndiana University School of Medicine, Division of Neonatal-Perinatal Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-5168-8904
Kok Lim KuaIndiana University School of Medicine, Division of Neonatal-Perinatal Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-6351-4506
Katie HuffIndiana University School of Medicine, Division of Neonatal-Perinatal Medicine, Indianapolis, Indiana, USA.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Investigating the Downstream Mechanisms Contributing to Beta Cell Failure in Offspring Exposed to Maternal ObesityK08HD109636 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI Kok Lim Kua · 2022 to 2026
$770k
NCATS NIH HHS UL1 TR002529NICHD NIH HHS K08 HD109636This publication was made possible, in part, by support from the Indiana Clinical and Translational Sciences Institute and, in part, by grant numbers UL1TR002529 (Caitlin Irwin) and K08HD109636 (Kok Lim Kua) from the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award, Riley Children's Foundation Physician Scientists Scholar Award, and March of Dimes Foundation.
6 · The paper itself

Abstract

backgroundEnteral feeding pump systems deliver decreased amounts of macronutrients in human milk to neonates. This study determined the macronutrient loss associated with a bottle-feeding pump system and the effect of manually mixing the human milk during extended feeds.

methodsMacronutrient content from samples of donor human milk was analyzed after simulated extended feeds with a bottle-feeding pump system, using a human milk analyzer. Simulations were repeated using manual mixing of the bottle every 30 min during feeding. The percentage of the baseline was calculated, and one-sample t tests and analysis of variance compared the effect of manual mixing and the duration of feeding on macronutrient delivery.

resultsThe delivery of fat and energy was lower over time, but manual mixing considerably improved retention. The length of feeding impacted fat delivery, with less fat delivered over time (P < 0.001). Manually mixing significantly increased fat delivery (P < 0.001). Similar results were found for energy, with a significant reduction in energy delivery over time (P < 0.001) and significantly more energy delivered with mixing (P < 0.001). Mixing and the duration of feeding had minimal effect on protein or carbohydrate delivery.

conclusionsBottle-feeding pump systems are associated with a significant reduction in the delivery of fat and energy of donor human milk. The manual mixing of donor human milk during prolonged feeds is a simple way to improve fat and energy delivery to the neonate.

Indexed as

Bottle FeedingDietary FatsEnergy IntakeEnteral NutritionMilk, HumanDietary ProteinsFemaleHumansInfant, NewbornInfant Nutritional Physiological PhenomenaNutrientsDietary FatsDietary ProteinsNutrientsenergy intakeenteral nutritionhuman milkinfantnutrients

Identifiers

PMID38884597
PMCPMC11293984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.