Evidence map›Paper›PMID 38884573›Full record

ArticleeLife2024

Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus.

John J Maurer, Alexandra Lin, Xi Jin, Jiso Hong, Nicholas Sathi, Romain Cardis, Alejandro Osorio-Forero, Anita Lüthi, Franz Weber, Shinjae Chung

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Role of Hypothalamic CRH Neurons in Regulating the Impact of Stress on Memory and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

John J MaurerDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0003-2710-1963
Alexandra LinDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Xi JinDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Jiso HongDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Nicholas SathiDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Romain CardisDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.
Alejandro Osorio-ForeroDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-4341-4206
Anita LüthiDepartment of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-4954-4143
Franz WeberDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Shinjae ChungDepartment of Neuroscience, Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.ORCID https://orcid.org/0000-0003-2268-563X

Funding

Sleep control by the preoptic area of the hypothalamusR01NS110865 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHUNG, SHINJAE · 2019 to 2023
$1.8M
Neuronal and homeostatic regulation of sleep by the preoptic area and tuberomammillary nucleusF31NS118963 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MAURER, JOHN · 2021 to 2023
$109k
NINDS NIH HHS F31 NS118963NINDS NIH HHS NS110865NINDS NIH HHS NS118963-01A1NINDS NIH HHS R01 NS110865
6 · The paper itself

Abstract

Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown. Here, we show that GABAergic neurons in the preoptic area of the hypothalamus projecting to the tuberomammillary nucleus (POA

Indexed as

GABAergic NeuronsHomeostasisPreoptic AreaSleep, REMAnimalsElectroencephalographyHypothalamic Area, LateralMaleMicemouseneurosciencepreoptic area of the hypothalamusrapid eye movement sleepsleep homeostasis

Identifiers

PMID38884573
PMCPMC11182646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.