Evidence map›Paper›PMID 38884570›Full record

ArticleInternational journal of urology : official journal of the Japanese Urological Association2024

Brain carbon monoxide can suppress the rat micturition reflex through brain γ-aminobutyric acid receptors.

Masaki Yamamoto, Takahiro Shimizu, Nobutaka Shimizu, Mikiya Fujieda, Motoaki Saito

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Article in International journal of urology : official journal of the Japanese Urological Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Masaki YamamotoDepartment of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Takahiro ShimizuDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Nobutaka ShimizuPelvic Floor Center, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.ORCID 0000-0003-4185-323X
Mikiya FujiedaDepartment of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
Motoaki SaitoDepartment of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.ORCID 0000-0002-2962-1607

Funding

Japan Society for the Promotion of Science 20K07827Japan Society for the Promotion of Science 21K09428Smoking Research FoundationThe Kochi Medical School Hospital President's Discretionary Grant
6 · The paper itself

Abstract

objectivesTo investigate roles of brain carbon monoxide (CO), an endogenous gasotransmitter, in regulation of the rat micturition reflex.

methodsIn urethane-anesthetized (0.8 g/kg, ip) male rats, evaluation of urodynamic parameters was started 1 h before intracerebroventricular administration of CORM-3 (CO donor) or ZnPP (non-selective inhibitor of heme oxygenase, a CO producing enzyme) and continued for 2 h after the administration. We also investigated effects of centrally pretreated SR95531 (GABA

resultsCORM-3 significantly prolonged intercontraction intervals (ICIs) without changing maximal voiding pressure (MVP), while ZnPP significantly shortened ICI and reduced single-voided volume and bladder capacity without affecting MVP, post-voided residual volume, or voiding efficiency. The ZnPP-induced ICI shortening was reversed by CORM-3. The CORM-3-induced ICI prolongation was significantly attenuated by centrally pretreated SR95531 or SCH50911, respectively.

conclusionsBrain CO can suppress the rat micturition reflex through brain γ-aminobutyric acid (GABA) receptors.

Indexed as

BrainCarbon MonoxideRats, Sprague-DawleyUrinary BladderUrinationAnimalsHeme Oxygenase (Decyclizing)MaleOrganometallic CompoundsRatsReceptors, GABAReceptors, GABA-AReflexUrodynamicsCarbon MonoxideHeme Oxygenase (Decyclizing)Organometallic CompoundsReceptors, GABAReceptors, GABA-Atricarbonylchloro(glycinato)ruthenium(II)braincarbon monoxideGABAA receptorGABAB receptormicturition reflex

Identifiers

PMID38884570
PMCPMC11524119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.