Evidence map›Paper›PMID 38884502›Full record

ReviewEpilepsia open2024

Water exchange across the blood-brain barrier and epilepsy: Review on pathophysiology and neuroimaging.

Myriam Abdennadher, Sara Jacobellis, Lena Václavů, Meher Juttukonda, Sara Inati, Lee Goldstein, Matthias J P van Osch, Bruce Rosen, Ning Hua, William Theodore

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Myriam AbdennadherNeurology Department, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7238-2560
Sara JacobellisBoston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Lena VáclavůC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Meher JuttukondaAthinoula A. Martinos Center of Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sara InatiNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-7587-5085
Lee GoldsteinPsychiatry and Neurology Department, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Matthias J P van OschC.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Bruce RosenAthinoula A. Martinos Center of Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Ning HuaRadiology Department, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
William TheodoreNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-4669-5747

Funding

Clinical and Translational Science Institute, Boston University 9500313034
6 · The paper itself

Abstract

The blood-brain barrier (BBB) is a barrier protecting the brain and a milieu of continuous exchanges between blood and brain. There is emerging evidence that the BBB plays a major role in epileptogenesis and drug-resistant epilepsy, through several mechanisms, such as water homeostasis dysregulation, overexpression of drug transporters, and inflammation. Studies have shown abnormal water homeostasis in epileptic tissue and altered aquaporin-4 water channel expression in animal epilepsy models. This review focuses on abnormal water exchange in epilepsy and describes recent non-invasive MRI methods of quantifying water exchange. PLAIN LANGUAGE SUMMARY: Abnormal exchange between blood and brain contribute to seizures and epilepsy. The authors describe why correct water balance is necessary for healthy brain functioning and how it is impacted in epilepsy. This review also presents recent MRI methods to measure water exchange in human brain. These measures would improve our understanding of factors leading to seizures.

Indexed as

Blood-Brain BarrierEpilepsyNeuroimagingAnimalsBrainHumansMagnetic Resonance ImagingWaterWaterarterial spin labelingblood–brain barrierepilepsyMRIseizurewater exchange

Identifiers

PMID38884502
PMCPMC11296120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.