Evidence map›Paper›PMID 38884133›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Islet-Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4-CXCL10 Axis.

Xiaoping Wu, Lai Yee Cheong, Lufengzi Yuan, Leigang Jin, Zixuan Zhang, Yang Xiao, Zhiguang Zhou, Aimin Xu, Ruby Lc Hoo, Lingling Shu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. CD8Nature reviews. Cardiology · 2026
    Review
  3. Evolving role of CD8Frontiers in immunology · 2026
    Review
  4. Islet Tissue Macrophages in Immunity Homeostasis and Type 1 Diabetes.Clinical reviews in allergy & immunology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoping WuState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Lai Yee CheongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Lufengzi YuanState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Leigang JinState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Zixuan ZhangState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Yang XiaoSecond Xiangya Hospital, Key Laboratory of Diabetes Immunology, National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, Hunan, 410083, P. R. China.
Zhiguang ZhouSecond Xiangya Hospital, Key Laboratory of Diabetes Immunology, National Clinical Research Center for Metabolic Diseases, Central South University, Changsha, Hunan, 410083, P. R. China.
Aimin XuState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Ruby Lc HooState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.
Lingling ShuState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, 999077, P. R. China.ORCID 0000-0002-3956-8563

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515010290Health Medical Research Fund 06172596Hong Kong Research Grants Council/Area of Excellence AoE/M-707/18National Key R&D Program of China 2022YFA0806102National Natural Science Foundation of China (NSFC) grants 82070860National Natural Science Foundation of China (NSFC) grants 82161138026Shenzhen-Hong Kong-Macau Science and Technology Program SGDX20210823103537031Sun Yat-sen University Hundred Talents Program PT19200101
6 · The paper itself

Abstract

Type 1 diabetes (T1D) is a chronic disease characterized by self-destruction of insulin-producing pancreatic β cells by cytotoxic T cell activity. However, the pathogenic mechanism of T cell infiltration remains obscure. Recently, tissue-resident memory T (T

Indexed as

Chemokine CXCL10Diabetes Mellitus, Type 1Fatty Acid-Binding ProteinsIslets of LangerhansMice, Inbred NODAnimalsDisease Models, AnimalHumansMemory T CellsMiceChemokine CXCL10Cxcl10 protein, mouseFabp4 protein, mouseFatty Acid-Binding ProteinsCXCL10CXCR3FABP4tissue‐resident memory T cellsType 1 diabetes

Identifiers

PMID38884133
PMCPMC11321687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.