Evidence map›Paper›PMID 38883899›Full record

ReviewThe Saudi dental journal2024

Application of BMP-2 and its gene delivery vehicles in dentistry.

Valeriya Sergeevna Kuznetsova, Andrey Vyacheslavovich Vasilyev, Tatiana Borisovna Bukharova, Irina Alekseevna Nedorubova, Dmitry Vadimovich Goldshtein, Vladimir Karpovich Popov, Anatoly Alekseevich Kulakov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Saudi dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valeriya Sergeevna KuznetsovaCentral Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Andrey Vyacheslavovich VasilyevCentral Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.
Tatiana Borisovna BukharovaResearch Centre for Medical Genetics, Moscow, Russia.
Irina Alekseevna NedorubovaResearch Centre for Medical Genetics, Moscow, Russia.
Dmitry Vadimovich GoldshteinResearch Centre for Medical Genetics, Moscow, Russia.
Vladimir Karpovich PopovFederal Scientific Research Centre "Crystallography and Photonics", Russian Academy of Sciences, Moscow, Russia.
Anatoly Alekseevich KulakovCentral Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The restoration of bone defects resulting from tooth loss, periodontal disease, severe trauma, tumour resection and congenital malformations is a crucial task in dentistry and maxillofacial surgery. Growth factor- and gene-activated bone graft substitutes can be used instead of traditional materials to solve these problems. New materials will overcome the low efficacy and difficulties associated with the use of traditional bone substitutes in complex situations. One of the most well-studied active components for bone graft substitutes is bone morphogenetic protein-2 (BMP-2), which has strong osteoinductive properties. The aim of this review was to examine the use of BMP-2 protein and gene therapy for bone regeneration in the oral and maxillofacial region and to discuss its future use.

Indexed as

BMP-2Bone morphogenetic proteinGene-activated materialsOsteogenesis

Identifiers

PMID38883899
PMCPMC11178965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.