Evidence map›Paper›PMID 38883880›Full record

ArticlePsychiatry and clinical psychopharmacology2024

Successful Use of High-Dose Brexpiprazole for Psychosis in Lewy Body Dementia without Adverse Effects.

Cho Lee, Shang-Hsuan Shih, Yu-Chih Shen

Abstract readCase Reports
In one paragraph

Article in Psychiatry and clinical psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cho LeeDepartment of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.ORCID 0000-0002-3896-7108
Shang-Hsuan ShihDepartment of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.ORCID 0009-0005-1639-1362
Yu-Chih ShenDepartment of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.ORCID 0000-0002-3503-5778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low doses of brexpiprazole (0.5-2 mg per day) have been tried to treat dementia-related psychosis/agitation and Parkinson's disease psychosis. We report a 71-year-old patient with a diagnosis of probable dementia with Lewy body (DLB) whose psychotic symptoms benefit from a higher dose of brexpiprazole (4 mg per day) without adverse effects. Though more studies were needed to confirm the safety and efficacy of brexpiprazole in the treatment of DLB, this case suggests that brexpiprazole is a potential treatment choice and it is safe even at the maximum daily dose (i.e., 4 mg per day).

Identifiers

PMID38883880
PMCPMC11177633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.