Evidence map›Paper›PMID 38883762›Full record

ArticleResearch square2024

Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency.

Rong Zhang, Xiaodan Mu, Dawei Liu, Chider Chen, Bowen Meng, Yan Qu, Jin Liu, Runci Wang, Chuanjie Li, Xueli Mao and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Rong ZhangGuangzhou Medical University.
Xiaodan MuCapital Medical University.
Dawei LiuPeking University School & Hospital of Stomatology.
Chider ChenUniversity of Pennsylvania.
Bowen MengSun Yat-sen University.
Yan QuSun Yat-sen University.
Jin LiuSichuan University.
Runci WangUniversity of Pennsylvania.
Chuanjie LiGuangzhou Medical University.
Xueli MaoSun Yat-sen University.
Qintao WangAir Force Medical University.
Qingbin ZhangGuangzhou Medical University.

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
OSTEOGENIC MECHANISMS OF SHEDR01DE017449 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHI, SONGTAO · 2007 to 2017
$3.5M
NIAMS NIH HHS P30 AR069619NIDCR NIH HHS R01 DE017449
6 · The paper itself

Abstract

Apoptotic vesicles (apoVs) play a vital role in various pathological conditions; however, we have yet to fully understand their precise biological effects in rescuing impaired mesenchymal stem cells (MSCs) and regulating tissue homeostasis. Here, we proved that systemic infusion of bone marrow MSCs derived from wild-type (WT) mice effectively improved the osteopenia phenotype and hyperimmune state in ovariectomized (OVX) mice. Importantly, the WT MSCs rescued the impairment of OVX MSCs both

Indexed as

Apoptotic vesiclesMesenchymal stem cellsmiR-145a-5pOsteoporosisTGF-β/Smad signalingWnt/β-catenin signaling

Identifiers

PMID38883762
PMCPMC11177995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.