ArticleResearch square2024
Midkine Attenuates Aβ Fibril Assembly and AmyloidPlaque Formation.
Junmin Peng, Masihuz Zaman, Shu Yang, Ya Huang, Jay Yarbro, Zhen Wang, Danting Liu, Hadeer Soliman, Alex Hemphill, Sarah Harvey and 16 more
Abstract readPreprint
In one paragraphArticle in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
26 authors.
Masihuz ZamanSt Jude Children's Research Hospital.
Shu YangSt Jude Children's Research Hospital.
Ya HuangSt Jude Children's Research Hospital.
Jay YarbroSt Jude Children's Research Hospital.
Zhen WangSt Jude Children's Research Hospital.
Danting LiuSt Jude Children's Research Hospital.
Hadeer SolimanSt Jude Children's Research Hospital.
Alex HemphillSt Jude Children's Research Hospital.
Sarah HarveySt Jude Children's Research Hospital.
Valerie StewartSt Jude Children's Research Hospital.
Ajay TanwarSt Jude Children's Research Hospital.
Martin TurkSt Jude Children's Research Hospital.
Yun JiaoSt Jude Children's Research Hospital.
Zhiping Wu
Anthony HighSt Jude Children's Research Hospital.
Xusheng WangSt Jude Children's Research Hospital.
Geidy SerranoBanner Sun Health Research Institute.
Thomas BeachBanner Sun Health Research Institute.
Yang YangVan Andel Institute.
Ping-Chung ChenSt Jude Children's Research Hospital.
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE J. BAKER · 1985 to 2026
$166.9MProject 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI ALISON M GOATE · 2021 to 2026
$42.0MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MResearch Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI THOMAS G BEACH · 2021 to 2026
$24.9MNational Brain and Tissue Resource for Parkinson's Disease and Related DisordersU24NS072026 · NINDS · BANNER SUN HEALTH RESEARCH INSTITUTE · PI BEACH, THOMAS G · 2011 to 2015
$7.8MSystems Approaches to Novel Molecular Mechanism in Alzheimer's DiseaseRF1AG064909 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PENG, JUNMIN, YU, GANG · 2019 to 2024
$6.4MDissecting neuron-microglia-astrocyte interaction in AD pathogenesisRF1AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2020 to 2023
$5.4MMulti-level Integrative Proteomics to Alzheimer's Disease PathwaysR01AG053987 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2020
$2.2MNCI NIH HHS P30 CA021765NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG053987NIA NIH HHS RF1 AG064909NIA NIH HHS RF1 AG068581NIA NIH HHS U19 AG069701NINDS NIH HHS U24 NS072026
6 · The paper itselfAbstract
Proteomic profiling of Alzheimer's disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with Aβ since the early disease stage, but their roles in disease progression are not fully understood. Here we present that MDK attenuates Aβ assembly and influences amyloid formation in the 5xFAD amyloidosis mouse model. MDK protein mitigates fibril formation of both Aβ40 and Aβ42 peptides in Thioflavin T fluorescence assay, circular dichroism, negative stain electron microscopy, and NMR analysis. Knockout of
Identifiers
PMID38883748
PMCPMC11177971
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