Evidence map›Paper›PMID 38883744›Full record

ArticleResearch square2024

Genome-wide association study of glucocerebrosidase activity modifiers.

Emma N Somerville, Lynne Krohn, Konstanin Senkevich, Eric Yu, Jamil Ahmad, Farnaz Asayesh, Jennifer A Ruskey, Dan Speigelman, Stanley Fahn, Cheryl Waters and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Emma N SomervilleThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Lynne KrohnThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Konstanin SenkevichThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Eric YuThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Jamil AhmadThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Farnaz AsayeshThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Jennifer A RuskeyThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Dan SpeigelmanThe Neuro (Montréal Neurological Institute-Hospital), McGill University.
Stanley FahnDepartment of Neurology, College of Physicians and Surgeons, Columbia University Medical Center.
Cheryl WatersDepartment of Neurology, College of Physicians and Surgeons, Columbia University Medical Center.
S Pablo SardiRare and Neurological Diseases Therapeutic Area, Sanofi.
Roy N AlcalayDepartment of Neurology, College of Physicians and Surgeons, Columbia University Medical Center.
Ziv Gan-OrThe Neuro (Montréal Neurological Institute-Hospital), McGill University.

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
The role of glucocerebrosidase in Parkinson's diseaseK02NS080915 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALCALAY, ROY · 2012 to 2016
$905k
NCRR NIH HHS UL1 RR024156NINDS NIH HHS K02 NS080915
6 · The paper itself

Abstract

One of the most common genetic risk factors for Parkinson's disease (PD) are variants in

Indexed as

GBA1Genome-wide association studyglucocerebrosidaselysosomal metabolismParkinson’s disease

Identifiers

PMID38883744
PMCPMC11177962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.