Evidence map›Paper›PMID 38883720›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease.

Bart E K S Swinnen, Colin W Hoy, Elena Pegolo, Elena Ubeda Matzilevich, Julia Sun, Bryony Ishihara, Francesca Morgante, Erlick Pereira, Fahd Baig, Michael Hart and 7 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Bart E K S SwinnenDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Colin W HoyDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Elena PegoloDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Elena Ubeda MatzilevichDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Julia SunDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Bryony IshiharaNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, United Kingdom.
Francesca MorganteNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, United Kingdom.
Erlick PereiraNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, United Kingdom.
Fahd BaigNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, United Kingdom.
Michael HartNeurosciences and Cell Biology Institute, Neuromodulation and Motor Control Section, St George's University of London, London, United Kingdom.
Huiling TanMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Zimi SawachaDepartment of Information Engineering, University of Padova, Padova, Italy.
Martijn BeudelDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
Sarah WangDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Philip StarrDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Simon LittleDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Lucia RicciardiDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.

Funding

Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
Identifying the neural mechanisms of goal-directed decision-making in Parkinson's disease using closed-loop deep brain stimulationF32MH132174 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOY, COLIN · 2023 to 2025
$232k
NIMH NIH HHS F32 MH132174NINDS NIH HHS K23 NS120037Wellcome Trust
6 · The paper itself

Abstract

Background: Neuropsychiatric symptoms are common and disabling in Parkinson's disease (PD), with troublesome anxiety occurring in one-third of patients. Management of anxiety in PD is challenging, hampered by insufficient insight into underlying mechanisms, lack of objective anxiety measurements, and largely ineffective treatments.In this study, we assessed the intracranial neurophysiological correlates of anxiety in PD patients treated with deep brain stimulation (DBS) in the laboratory and at home. We hypothesized that low-frequency (theta-alpha) activity would be associated with anxiety. Methods: We recorded local field potentials (LFP) from the subthalamic nucleus (STN) or the globus pallidus pars interna (GPi) DBS implants in three PD cohorts: 1) patients with recordings (STN) performed in hospital at rest via perioperatively externalized leads, without active stimulation, both ON or OFF dopaminergic medication; 2) patients with recordings (STN or GPi) performed at home while resting, via a chronically implanted commercially available sensing-enabled neurostimulator (Medtronic Percept Results: In total, 33 PD patients (59 hemispheres) were included. Across three independent cohorts, with stimulation OFF, basal ganglia theta power was positively related to trait anxiety (all p<0.05). Also in a naturalistic setting, with individuals at home at rest with stimulation and medication ON, basal ganglia theta power was positively related to trait anxiety (p<0.05). This relationship held regardless of the hemisphere and DBS target. There was no correlation between trait anxiety and premotor cortical theta-alpha power. There was no within-patient association between basal ganglia theta-alpha power and state anxiety. Conclusion: We showed that basal ganglia theta activity indexes trait anxiety in PD. Our data suggest that theta could be a possible physiomarker of neuropsychiatric symptoms and specifically of anxiety in PD, potentially suitable for guiding advanced DBS treatment tailored to the individual patient's needs, including non-motor symptoms.

Indexed as

anxietydeep brain stimulationlocal field potentialnon-motor symptomsParkinson’s disease

Identifiers

PMID38883720
PMCPMC11177918

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.