Evidence map›Paper›PMID 38883705›Full record

ArticleResearch square2024

Comprehensive Analyses of the Effects of the Small-Molecule Inhibitor of the UHM Domain in the Splicing Factor

Xinrui Yuan, Mona Kazemi Sabzvar, Amol D Patil, Krishnapriya Chinnaswamy, Kathryn L Howie, Ramaraju Andhavaram, Borwyn Wang, Maxime A Siegler, Arda Dumaz, Jeanne A Stuckey and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinrui YuanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mona Kazemi SabzvarDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Amol D PatilDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Krishnapriya ChinnaswamyLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Kathryn L HowieDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ramaraju AndhavaramDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Borwyn WangDepartments of Pediatrics and Cancer Biology, Cleveland Clinic, Cleveland, OH, 44195, USA.
Maxime A SieglerDepartment of Chemistry, John Hopkins University, Baltimore, MD, 21218, USA.
Arda DumazDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Jeanne A StuckeyLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4192-8900
Seth J CoreyDepartments of Pediatrics and Cancer Biology, Cleveland Clinic, Cleveland, OH, 44195, USA.
Jaroslaw P MaciejewskiDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.ORCID 0000-0002-6837-4346
Valeria VisconteDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.ORCID 0000-0002-2993-1509
Chao-Yie YangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-5445-0109

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Single Crystal X-ray Diffractometer with Microfocus Rotating Anode Source (Cu)S10OD030352 · OD · JOHNS HOPKINS UNIVERSITY · PI SIEGLER, MAXIME A · 2022 to 2022
$471k
Targeting defective spliceosomal pathway in myeloid malignanciesR21CA270590 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI VISCONTE, VALERIA, YANG, CHAO-YIE · 2022 to 2023
$411k
NCI NIH HHS P30 CA046592NCI NIH HHS R21 CA270590NIH HHS S10 OD030352
6 · The paper itself

Abstract

Mutations in RNA splicing factor genes including

Indexed as

clathrincollagenendocytosisHTRFmyeloid malignanciesRNARNA splicingU2AF2U2 small nuclear RNA auxiliary factor 1UHMULM

Identifiers

PMID38883705
PMCPMC11177969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.