ArticleLaser & photonics reviews2023
Roadmap on Label-Free Super-Resolution Imaging.
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Article in Laser & photonics reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
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29 citing papers in PubMed.
- 'In silico labelling': Exploring the biological landscape at the nanoscale using intelligent multimodal optical microscopy.Journal of microscopy · 2026Review
- Intrinsically co-registered extended-depth-of-focus OCM and two-photon microscopy for label-free volumetric analysis of 3D cell models.Biomedical optics express · 2026Article
- Photonic and Optoelectronic Devices and Systems, 4th Edition.Micromachines · 2026Article
- Exploring cross-regional and cross-variable transferability of a ResNet-based super-resolution method for the ERA5 data.Scientific reports · 2026Article
- Brain-SAM: a general automatic SAM-based segmentation model for brain science images.Biomedical optics express · 2026Article
- Meta-amplified dark-field interferometric scattering microscopy.Nature communications · 2026Article
- Super-resolution imaging of limited-size objects.Nature photonics · 2026Article
- LensPlus: a high space-bandwidth optical imaging technique.Biomedical optics express · 2026Article
- FACE-ing the future of single-pixel complex-field microscopy beyond the visible spectrum.Light, science & applications · 2026Article
- Label free super resolution imaging with photonic nanojets from tunable tapered optical fibers.Nanophotonics (Berlin, Germany) · 2025Article
- Gentle Label-Free Nonlinear Optical Imaging Relaxes Linear-Absorption-Mediated Triplet.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- MINFLUX nanoscopy enhanced with high-order vortex beams.Light, science & applications · 2025Article
- Single-molecule manipulation and detection by WGM-coupled photonic nanojets.Discover nano · 2025Article
- Precise Sizing and Collision Detection of Functional Nanoparticles by Deep Learning Empowered Plasmonic Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Planar device-enabled speckle illumination for dark-field label-free imaging beyond the diffraction limit.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Superresolution based on coherent thermal radiation with selective information.Discover nano · 2025Article
- Nanophotonic inspection of deep-subwavelength integrated optoelectronic chips.Science advances · 2025Article
- Review
- Dynamic imaging of myelin pathology in physiologically preserved human brain tissue using third harmonic generation microscopy.PloS one · 2025Article
- Molecular Fingerprinting of Mouse Brain Using Ultrabroadband Coherent Anti-Stokes Raman Scattering (CARS) Microspectroscopy Empowered by Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS).Chemical & biomedical imaging · 2024Article
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Authors and funding
54 authors.
Vasily N AstratovDepartment of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, USA.
Yair Ben SahelDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Yonina C EldarDepartment of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Luzhe HuangElectrical and Computer Engineering Department, University of California, Los Angeles, California 90095, USA.
Aydogan OzcanElectrical and Computer Engineering Department, University of California, Los Angeles, California 90095, USA.
Nikolay ZheludevOptoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK.
Junxiang ZhaoDepartment of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Zachary BurnsDepartment of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Zhaowei LiuDepartment of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Evgenii NarimanovSchool of Electrical Engineering, and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA.
Neha GoswamiQuantitative Light Imaging Laboratory, Beckman Institute of Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois 61801, USA.
Gabriel PopescuQuantitative Light Imaging Laboratory, Beckman Institute of Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois 61801, USA.
Emanuel PfitznerDepartment of Chemistry, University of Oxford, Oxford OX1 3QZ, United Kingdom.
Philipp KukuraDepartment of Chemistry, University of Oxford, Oxford OX1 3QZ, United Kingdom.
Yi-Teng HsiaoInstitute of Atomic and Molecular Sciences (IAMS), Academia Sinica 1, Roosevelt Rd. Sec. 4, Taipei 10617 Taiwan.
Chia-Lung HsiehInstitute of Atomic and Molecular Sciences (IAMS), Academia Sinica 1, Roosevelt Rd. Sec. 4, Taipei 10617 Taiwan.
Brian AbbeyAustralian Research Council Centre of Excellence for Advanced Molecular Imaging, La Trobe University, Melbourne, Victoria, Australia.
Alberto DiasproOptical Nanoscopy and NIC@IIT, CHT, Istituto Italiano di Tecnologia, Via Enrico Melen 83B, 16152 Genoa, Italy.
Aymeric LeGratietOptical Nanoscopy and NIC@IIT, CHT, Istituto Italiano di Tecnologia, Via Enrico Melen 83B, 16152 Genoa, Italy.
Paolo BianchiniOptical Nanoscopy and NIC@IIT, CHT, Istituto Italiano di Tecnologia, Via Enrico Melen 83B, 16152 Genoa, Italy.
Natan T ShakedTel Aviv University, Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv 6997801, Israel.
Bertrand SimonLP2N, Institut d'Optique Graduate School, CNRS UMR 5298, Université de Bordeaux, Talence France.
Nicolas VerrierIRIMAS UR UHA 7499, Université de Haute-Alsace, Mulhouse, France.
Matthieu DebailleulIRIMAS UR UHA 7499, Université de Haute-Alsace, Mulhouse, France.
Olivier HaeberléIRIMAS UR UHA 7499, Université de Haute-Alsace, Mulhouse, France.
Sheng WangSchool of Physics and Technology, Wuhan University, China.
Mengkun LiuDepartment of Physics and Astronomy, Stony Brook University, USA.
Yeran BaiBoston University Photonics Center, Boston, MA 02215, USA.
Ji-Xin ChengBoston University Photonics Center, Boston, MA 02215, USA.
Behjat S KarimanOptical Nanoscopy and NIC@IIT, CHT, Istituto Italiano di Tecnologia, Via Enrico Melen 83B, 16152 Genoa, Italy.
Katsumasa FujitaDepartment of Applied Physics and the Advanced Photonics and Biosensing Open Innovation Laboratory (AIST); and the Transdimensional Life Imaging Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.
Moshe SinvaniFaculty of Engineering and the Nano-Technology Center, Bar-Ilan University, Ramat Gan, 52900 Israel.
Zeev ZalevskyFaculty of Engineering and the Nano-Technology Center, Bar-Ilan University, Ramat Gan, 52900 Israel.
Xiangping LiGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.
Guan-Jie HuangDepartment of Physics and Molecular Imaging Center, National Taiwan University, Taipei 10617, Taiwan.
Shi-Wei ChuDepartment of Physics and Molecular Imaging Center, National Taiwan University, Taipei 10617, Taiwan.
Omer TzangSchool of Chemistry, The Sackler faculty of Exact Sciences, and the Center for Light matter Interactions, and the Tel Aviv University Center for Nanoscience and Nanotechnology, Tel Aviv 69978, Israel.
Dror HershkovitzSchool of Chemistry, The Sackler faculty of Exact Sciences, and the Center for Light matter Interactions, and the Tel Aviv University Center for Nanoscience and Nanotechnology, Tel Aviv 69978, Israel.
Ori CheshnovskySchool of Chemistry, The Sackler faculty of Exact Sciences, and the Center for Light matter Interactions, and the Tel Aviv University Center for Nanoscience and Nanotechnology, Tel Aviv 69978, Israel.
Mikko J HuttunenLaboratory of Photonics, Physics Unit, Tampere University, FI-33014, Tampere, Finland.
Stefan G StanciuCenter for Microscopy - Microanalysis and Information Processing, Politehnica University of Bucharest, 313 Splaiul Independentei, 060042, Bucharest, Romania.
Vera N SmolyaninovaDepartment of Physics Astronomy and Geosciences, Towson University, 8000 York Rd., Towson, MD 21252, USA.
Igor I SmolyaninovDepartment of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.
Ulf LeonhardtWeizmann Institute of Science, Rehovot 7610001, Israel.
Sahar SahebdivanEMTensor GmbH, TechGate, Donau-City-Strasse 1, 1220 Wien, Austria.
Zengbo WangSchool of Computer Science and Electronic Engineering, Bangor University, Bangor, LL57 1UT, United Kingdom.
Boris Luk'yanchukFaculty of Physics, Lomonosov Moscow State University, Moscow 119991, Russia.
Limin WuDepartment of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
Alexey V MaslovDepartment of Radiophysics, University of Nizhny Novgorod, Nizhny Novgorod, 603022, Russia.
Boya JinDepartment of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, USA.
Constantin R SimovskiDepartment of Electronics and Nano-Engineering, Aalto University, FI-00076, Espoo, Finland.
Stephane PerrinICube Research Institute, University of Strasbourg - CNRS - INSA de Strasbourg, 300 Bd. Sébastien Brant, 67412 Illkirch, France.
Paul MontgomeryICube Research Institute, University of Strasbourg - CNRS - INSA de Strasbourg, 300 Bd. Sébastien Brant, 67412 Illkirch, France.
Sylvain LeclerICube Research Institute, University of Strasbourg - CNRS - INSA de Strasbourg, 300 Bd. Sébastien Brant, 67412 Illkirch, France.
Funding
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7MRapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7MQuantitative histopathology for cancer prognosis using quantitative phase imaging on stained tissuesR01CA238191 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANASTASIO, MARK A, ELICEIRI, KEVIN WILLIAM · 2019 to 2023
$3.1MHigh accuracy optical growth assay of 3D cellular systemsR01GM129709 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID · 2019 to 2022
$2.1MNCI NIH HHS R01 CA238191NIAID NIH HHS R01 AI141439NIGMS NIH HHS R01 GM129709NIGMS NIH HHS R35 GM136223
Abstract
Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles which need to be overcome to break the classical diffraction limit of the LFSR imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability which are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.
Indexed as
absorptionartificial intelligencebiomedical imagingconfocal microscopydeep learningdiffractiondiffraction limitfocusinghigh-resolution imagingholographyinterferencelabel-free imagingmetamaterialsmicrolens designmicroresonatorsmicrospheresnanoplasmonicsnear-field imagingoptical microscopyphotonic crystalspolarizationpropagationRaman microscopyreflectivityscatteringsolid immersion lensspectroscopystructured illuminationsuperlenssuper-resolutiontomographytransformation optics
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