Evidence map›Paper›PMID 38883380›Full record

ArticleAmerican journal of translational research2024

Abnormal methylation of HOXA11 promoter promotes tumor progression in testicular germ cell tumor.

Juan He, Liang Li, Shengxin Wang, Shan Wu, Wenli Xiao, Li Li, Li Dong, An Ge, Kaikai Xie, Jiaomin Wang

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Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Juan HeDepartment of Pathology, The Institutes of Shanxi Bethune Hospital Taiyuan 030032, Shanxi, China.
Liang LiInstitutes of Biomedical Sciences, Shanxi University Taiyuan 030006, Shanxi, China.
Shengxin WangInstitutes of Biomedical Sciences, Shanxi University Taiyuan 030006, Shanxi, China.
Shan WuDepartment of Radiology, The Institutes of Shanxi Bethune Hospital Taiyuan 030032, Shanxi, China.
Wenli XiaoDepartment of Ultrasonography, The Institutes of Shanxi Bethune Hospital Taiyuan 030032, Shanxi, China.
Li LiDepartment of Pathology, The Institutes of Shanxi Bethune Hospital Taiyuan 030032, Shanxi, China.
Li DongInstitutes of Biomedical Sciences, Shanxi University Taiyuan 030006, Shanxi, China.
An GeInstitutes of Biomedical Sciences, Shanxi University Taiyuan 030006, Shanxi, China.
Kaikai XieInstitutes of Biomedical Sciences, Shanxi University Taiyuan 030006, Shanxi, China.
Jiaomin WangDepartment of Foreign Language, Shanxi Medical University Taiyuan 030006, Shanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the methylation of HOXA11 gene promoter in testicular germ cell tumor (GCT).

methodThe clinicopathological data of 63 patients with primary testicular GCT who underwent surgery during Apr. 2019 to Mar. 2021, were retrospectively analyzed. Their GCT tissue and paraneoplastic testicular tissue were obtained, and genomic DNA was extracted from both. The methylation of HOXA11 gene promoter region was detected by methylation-specific PCR (MSP). The incidence of HOXA11 methylation in testicular GCT and adjacent tissues was compared, and the connection between methylation level in testicular GCT and clinicopathologic features of patients was statistically analyzed. Testicular GCT cells were treated with methylated transferase inhibitor 5-Aza-dC

resultsThe positive rate of HOXA11 promoter methylation in testicular GCT tissues was notably higher than that of paired adjacent tissues (

conclusionAbnormal methylation of HOXA11 gene promoter in testicular germ cell tumor tissue inhibits transcription and expression of HOXA11 gene. The abnormal methylation of HOXA11 promoter region is tightly associated with lymph node metastasis and TNM staging in testicular germ cell tumors.

Indexed as

gene promoter methylationgerm cell tumorHOXA11 geneTesticle

Identifiers

PMID38883380
PMCPMC11170575

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