Evidence map›Paper›PMID 38883371›Full record

ArticleAmerican journal of translational research2024

E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice.

Tiantian Wu, Xin Jin, Chao Huang, Xiangling Yu, Bingya Xu, Wenxin Gao, Xiya Qiu, Mingyuan Bao, Dan Zhao, Guannan Feng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. WSB1 is dispensable for mouse spermatogenesis and male fertility.American journal of translational research · 2026
    Article
  2. American journal of translational research · 2025
    Article
  3. Testis-enrichedAmerican journal of translational research · 2025
    Article
  4. Testis-enrichedAmerican journal of translational research · 2025
    Article
  5. Dcun1d3 is dispensable for spermatogenesis and male fertility in mice.American journal of clinical and experimental immunology · 2025
    Article
  6. DCUN1D2 is insignificant for spermatogenesis and male fertility in mice.American journal of translational research · 2025
    Article
  7. SERINC4 is dispensable for male fertility and spermatogenesis in mice.American journal of translational research · 2025
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tiantian WuState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Xin JinDepartment of Obstetrics and Gynecology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Chao HuangState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Xiangling YuHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214122, Jiangsu, China.
Bingya XuHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214122, Jiangsu, China.
Wenxin GaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Xiya QiuState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Mingyuan BaoState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.
Dan ZhaoFourth Affiliated Hospital of Jiangsu University Zhenjiang 212008, Jiangsu, China.
Guannan FengDepartment of Obstetrics and Gynecology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Bo ZhengState Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, Jiangsu, China.
Xiaoyan HuangState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundF-box-only protein 22 (FBXO22), an important substrate receptor of the SKP1-Cullin-F-box (SCF) ubiquitin ligases, has been reported to be involved in many biological processes, including tumorigenesis, neurological disorders, cellular senescence, and DNA damage. However, the specific role of FBXO22 during spermatogenesis is poorly understood.

methodsWe produced

resultsOur results revealed that there were no notable differences in semen quality, fertility test results, or histologic findings in

conclusionsOur study demonstrated that

Indexed as

Fbxo22knockoutmale fertilityspermatogenesis

Identifiers

PMID38883371
PMCPMC11170574

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.