Evidence map›Paper›PMID 38883349›Full record

ReviewAmerican journal of translational research2024

Liquid biopsy to personalize treatment for metastatic prostate cancer.

Marta Lopez-Valcarcel, Fernando Lopez-Campos, Juan Zafra, Irene Cienfuegos, Maria Ferri, Marta Barrado, Susana Hernando, Felipe Counago

Abstract readReview
In one paragraph

Review in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marta Lopez-ValcarcelDepartment of Radiation Oncology, Puerta de Hierro University Hospital Madrid, Spain.
Fernando Lopez-CamposDepartment of Radiation Oncology, Ramon y Cajal University Hospital Madrid, Spain.
Juan ZafraDepartment of Radiation Oncology, Virgen de la Victoria University Hospital Málaga, Spain.
Irene CienfuegosDepartment of Urology, Virgen del Puerto Hospital Plasencia, Cáceres, Extremadura, Spain.
Maria FerriDepartment of Radiation Oncology, Marques de Valdecilla University Hospital Santander, Cantabria, Spain.
Marta BarradoDepartment of Radiation Oncology, Navarra University Hospital Pamplona, Navarra, Spain.
Susana HernandoDepartment of Clinical Oncology, Fundación Alcorcon University Hospital Alcorcón, Madrid, Spain.
Felipe CounagoDepartment of Radiation Oncology, GenesisCare Madrid Clinical Director, San Francisco de Asis and La Milagrosa Hospitals, National Chair of Research and Clinical Trials GenesisCare, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsy is an innovative approach that provides a more complete understanding of treatment response and prognosis in monitoring metastatic prostate cancer. It complements invasive tissue biopsy and involves the assessment of various biomarkers in body fluids such as blood, semen, and urine. Liquid biopsy analyzes circulating tumor cells, extracellular vesicles, circulating tumor DNA, and the secretome. This is particularly important given the heterogeneity of prostate cancer and the need for better prognostic biomarkers. Liquid biopsy can personalize the treatment of homonosensitive and castration-resistant metastatic prostate cancer by acting as a predictive and prognostic tool. This review discusses various biomarkers, assay techniques, and potential applications in daily clinical practice, highlighting the exciting possibilities that this emerging field holds for improving patient outcomes.

Indexed as

circulating tumor cellscirculating tumor DNAextracellular vesiclesLiquid biopsyprostate cancersecretome

Identifiers

PMID38883349
PMCPMC11170619

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.