ArticleBioactive materials2024
A cuttlefish ink nanoparticle-reinforced biopolymer hydrogel with robust adhesive and immunomodulatory features for treating oral ulcers in diabetes.
Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Water-responsive injectable hydrogel achieving rapid in situ gelation and long-term colonic mucoadhesion for efficient fecal microbiota transplantation.Bioactive materials · 2027Article
- Stage-aligned electro-ionic biobattery hydrogel for enhanced wound closure and scar reduction.Bioactive materials · 2027Article
- Hyaluronic acid-based osmolality-responsive immediate-release microneedles co-loading baicalein and astaxanthin for oral ulcer therapy.Materials today. Bio · 2026Article
- Study on the repair effect of photothermal hydrogel with controllable adhesiveness regulated by melanin and magnesium ions on diabetic wounds.Bioactive materials · 2026Article
- Integrated apoptotic extracellular vesicle-recruitment peptide coating reprograms the diabetic bone microenvironment and orchestrates enhanced implant osseointegration.Bioactive materials · 2026Article
- An injectable tough hydrogel sealant enabling rapid hemostasis and promoting oral tissue regeneration.Bioactive materials · 2026Article
- A biomimetic core-shell nanofibrous dressing for temporally coordinated infection control and mitochondrial protection in diabetic wounds.Materials today. Bio · 2026Article
- Spatiotemporally responsive hybrid hydrogels for sequential therapy and visualized monitoring of multidrug-resistant bacterial wound infections.Bioactive materials · 2026Article
- The potential of calcitriol gel in accelerating the healing of traumatic oral ulcers.Journal of Taibah University Medical Sciences · 2026Article
- Enhancing the therapeutic efficacy of dexamethasone for oral ulcers through adhesive gelatin hydrogel-based nano-delivery system.Materials today. Bio · 2026Article
- Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy.Bioactive materials · 2026Article
- Photothermal-Chemotherapeutic Microneedle Patch Coloaded with HMnOACS applied materials & interfaces · 2026Article
- Adhesive Hydrogel Loaded with Sulfonated Chitosan Promotes Oral Mucosal Defect Repair in Diabetic Rats.Bioengineering (Basel, Switzerland) · 2026Article
- Silk-Fibroin-Based Adhesive Hydrogels: Mechanistic Insights and Biomedical ApplicationsA Review.ACS omega · 2026Review
- A nature-derived, strong adhesive hydrogel microsphere for wet tissue repair: Multifunctional and clinical potential.Bioactive materials · 2026Article
- Structural Characterization and Wound Healing Activity of Sulfated Glycosaminoglycans from Acipenser Baerii Cartilage: Potential Regulation of Fibroblast Function.Macromolecular bioscience · 2026Article
- Impact of a Reinforced Graphene Oxide and Alginate Hydrogel with an Oxygen Releasing System on the Biocompatibility of Pancreatic β-Cells for Diabetes Therapy.Macromolecular bioscience · 2026Article
- A multimodal ROS logic-gated therapeutic platform disrupts the vicious cycle of senescence to promote aged bone defect repair.Bioactive materials · 2026Article
- Cuttlefish Ink-Derived Melanin Nanoparticles Enabling NIR-Responsive Electrospun Nanofibrous Mats for On-Demand Selective Antibacterial Disinfection of Orthodontic Braces.ACS applied materials & interfaces · 2026Article
- ONX-0914 Alleviates Impaired Diabetic Wound Healing by Restoring Redox Homeostasis and Modulating Pro-Inflammatory Response.Medicina (Kaunas, Lithuania) · 2026Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral ulcers can be managed using a variety of biomaterials that deliver drugs or cytokines. However, many patients experience minimal benefits from certain medical treatments because of poor compliance, short retention times in the oral cavity, and inadequate drug efficacy. Herein, we present a novel hydrogel patch (SCE2) composed of a biopolymer matrix (featuring ultraviolet-triggered adhesion properties) loaded with cuttlefish ink nanoparticles (possessing pro-healing functions). Applying a straightforward local method initiates the formation of a hydrogel barrier that adheres to mucosal injuries under the influence of ultraviolet light. SCE2 then demonstrates exceptional capabilities for near-infrared photothermal sterilization and neutralization of reactive oxygen species. These properties contribute to the elimination of bacteria and the management of the oxidation process, thus accelerating the healing phase's progression from inflammation to proliferation. In studies involving diabetic rats with oral ulcers, the SCE2 adhesive patch significantly quickens recovery by altering the inflamed state of the injured area, facilitating rapid re-epithelialization, and fostering angiogenesis. In conclusion, this light-sensitive hydrogel patch offers a promising path to expedited wound healing, potentially transforming treatment strategies for clinical oral ulcers.
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