Evidence map›Paper›PMID 38883063›Full record

ArticleCureus2024

Rapidly Progressing Secondary Organizing Pneumonia Due to Underlying Immunosuppression With Rituximab in SARS-CoV-2 Patients.

Madeline Vithya Barnaba Durairaj, Hayden Caraway, Robert Buresh, Rahul Sampath, Simon Waghchoure

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madeline Vithya Barnaba DurairajInternal Medicine, University of North Carolina (UNC) Health Blue Ridge, Morganton, USA.
Hayden CarawayInternal Medicine, University of North Carolina (UNC) Health Blue Ridge, Morganton, USA.
Robert BureshPathology, University of North Carolina (UNC) Health Blue Ridge, Morganton, USA.
Rahul SampathInfectious Disease, University of North Carolina (UNC) Health Blue Ridge, Morganton, USA.
Simon WaghchoureIntensive Care Unit, University of North Carolina (UNC) Health Blue Ridge, Morganton, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary organizing pneumonia (SOP) as a sequela to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually has a prolonged benign course with a good response to corticosteroids. We present a case series of three patients who developed rapid progression to organizing pneumonia, after initial presentation with SARS-CoV-2. Imaging revealed rapid interval progression of bilateral subpleural ground glass opacities, and lung biopsy showed dense fibroblastic plugs within the alveoli. Two patients were steroid-responsive, and one patient succumbed to his illness despite maximal therapy. We postulate that B-cell depletion and immunosuppression may cause rapid progression to SOP, as all three patients were immunosuppressed and on chronic rituximab therapy.

Indexed as

covid-19immunosuppressionlungrituximabsecondary organizing pneumonia

Identifiers

PMID38883063
PMCPMC11177329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.