Evidence map›Paper›PMID 38882697›Full record

ArticleFrontiers in neurology2024

Elevated lipopolysaccharide binding protein in Alzheimer's disease patients with

Eduardo Z Romo, Brian V Hong, Rishi Y Patel, Joanne K Agus, Danielle J Harvey, Izumi Maezawa, Lee-Way Jin, Carlito B Lebrilla, Angela M Zivkovic

Abstract read
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. From Tradition to Translation: A Critical Appraisal ofInternational journal of molecular sciences · 2026
    Review
  3. Review
  4. Open medicine (Warsaw, Poland) · 2026
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eduardo Z RomoDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Brian V HongDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Rishi Y PatelDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Joanne K AgusDepartment of Nutrition, University of California, Davis, Davis, CA, United States.
Danielle J HarveyDepartment of Public Health Sciences, University of California, Davis, Davis, CA, United States.
Izumi MaezawaDepartment of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Lee-Way JinDepartment of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Davis, CA, United States.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, Davis, CA, United States.
Angela M ZivkovicDepartment of Nutrition, University of California, Davis, Davis, CA, United States.

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Comprehensive Characterization of Glycosylation Alterations in Alzheimer’s DiseaseR01AG062240 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JIN, LEE-WAY, LEBRILLA, CARLITO B · 2018 to 2022
$3.3M
Development of a Novel Technology for Preparative Fractionation and Characterization of Lipoprotein ParticlesR01GM147545 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZIVKOVIC, ANGELA M · 2022 to 2025
$1.2M
NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG062240NIGMS NIH HHS R01 GM147545
6 · The paper itself

Abstract

Introduction: The role of lipopolysaccharide binding protein (LBP), an inflammation marker of bacterial translocation from the gastrointestinal tract, in Alzheimer's disease (AD) is not clearly understood. Methods: In this study the concentrations of LBP were measured in Results: LBP was significantly increased within the 1.21-1.25 g/mL density fraction of plasma in Discussion: These results underscore the potential contribution of gut permeability to bacterial toxins, measured as LBP, as an inflammatory mediator in the development of AD, particularly in individuals with the

Indexed as

Alzheimer’s diseaseApoE3/E3 genotypeApoE3/E4 genotypegut permeabilitylipopolysaccharide binding protein

Identifiers

PMID38882697
PMCPMC11177782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.