Evidence map›Paper›PMID 38882538›Full record

ReviewInternational journal of nanomedicine2024

Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review.

Hanna Dilenko, Kateřina Bartoň Tománková, Lucie Válková, Barbora Hošíková, Markéta Kolaříková, Lukáš Malina, Robert Bajgar, Hana Kolářová

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  16. Functionalized Nanomaterials in Cancer Treatment: A Review.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanna DilenkoDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID 0000-0002-8801-2094
Kateřina Bartoň TománkováDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID 0000-0002-3249-4522
Lucie VálkováDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID 0000-0003-3854-1091
Barbora HošíkováDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID 0000-0003-4373-3469
Markéta KolaříkováDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID 0000-0002-4745-2667
Lukáš MalinaDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.ORCID 0000-0001-5734-5921
Robert BajgarDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Hana KolářováDepartment of Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a non-invasive therapy that has made significant progress in treating different diseases, including cancer, by utilizing new nanotechnology products such as graphene and its derivatives. Graphene-based materials have large surface area and photothermal effects thereby making them suitable candidates for PDT or photo-active drug carriers. The remarkable photophysical properties of graphene derivates facilitate the efficient generation of reactive oxygen species (ROS) upon light irradiation, which destroys cancer cells. Surface functionalization of graphene and its materials can also enhance their biocompatibility and anticancer activity. The paper delves into the distinct roles played by graphene-based materials in PDT such as photosensitizers (PS) and drug carriers while at the same time considers how these materials could be used to circumvent cancer resistance. This will provide readers with an extensive discussion of various pathways contributing to PDT inefficiency. Consequently, this comprehensive review underscores the vital roles that graphene and its derivatives may play in emerging PDT strategies for cancer treatment and other medical purposes. With a better comprehension of the current state of research and the existing challenges, the integration of graphene-based materials in PDT holds great promise for developing targeted, effective, and personalized cancer treatments.

Indexed as

Drug Resistance, NeoplasmGraphiteNeoplasmsPhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesAnimalsDrug CarriersHumansDrug CarriersGraphitePhotosensitizing AgentsReactive Oxygen Speciescancer researchdrug deliverygraphene oxidegraphene quantum dotsphotosensitizers

Identifiers

PMID38882538
PMCPMC11179671

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.