Evidence map›Paper›PMID 38882178›Full record

ArticleJournal of clinical and experimental hepatology

Medically Tailored Meals for Patients With Cirrhosis and Hepatic Encephalopathy: The BRAINFOOD Proof-of-concept Trial.

Elliot B Tapper, Zachary M Saleh, Sam Nikirk, Jasmohan Bajaj, Xi Chen, Anna S-F Lok

Abstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Nutrition and Culinary Education in Food Is Medicine Interventions: A Scoping Review.Journal of the Academy of Nutrition and Dietetics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Medically Tailored Meal for Hepatic Encephalopathy: More ThanJournal of clinical and experimental hepatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elliot B TapperDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Zachary M SalehDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Sam NikirkDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Jasmohan BajajDepartment of Internal Medicine, Virginia Commonwealth University, Richmond VA, USA.
Xi ChenDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Anna S-F LokDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

Funding

Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
NIA NIH HHS P30 AG024824
6 · The paper itself

Abstract

Background and aims: Guidelines recommend that patients with hepatic encephalopathy (HE) receive a high-protein diet (roughly 1 g/kg actual body weight). Concommitant sodium restriction, low health literacy, and food insecurity limit patients' ability to meet this goal. We aimed to determine the feasibility of home-delivered high-protein medically tailored meals (MTMs) for patients with a recent episode of overt HE. Methods: We enrolled patients with prior overt HE on active HE therapy in a 6-month trial of MTM. All received 21 home-delivered meals/week with protein snacks (mid-day and bedtime) for 12 weeks. Patients completed follow-up at week 24. The primary outcome was feasibility. Additional outcomes included change in protein and micronutrient intake (measured using 24 h dietary recalls performed by dieticians), cognitive function (Animal Naming Test [ANT]; EncephalApp Stroop), physical function (Liver Frailty Index [LFI]), and quality of life (Short Form-8 Health Survey [SF-8]). Healthcare utilization was also assessed. Results: Ten patients competed the study with >90% of MTM consumed. Protein intake rose from 74.6 ± 25.1 g at baseline to 93.8 ± 24.3 g on MTM ( Conclusion: Home-delivered MTMs are feasible, increase protein consumption, and may improve patient wellbeing. A randomized trial is needed.

Indexed as

asciteslivermalnutritionprotein

Identifiers

PMID38882178
PMCPMC11176801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.