Evidence map›Paper›PMID 38882094›Full record

ArticleACS omega2024

Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity.

Ramon M Cogo, Thaís F A Pavani, Ana C A Mengarda, Rayssa A Cajas, Thainá R Teixeira, Lucas Fukui-Silva, Yujie Uli Sun, Lawrence J Liu, Dilini K Amarasinghe, Michael C Yoon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ramon M CogoUniversidade Federal de São Paulo-Campus Diadema, Curso de Pós-Graduação em Biologia Química da Unifesp, Rua São Nicolau 210, 2o andar, Centro, Diadema, São Paulo 09972-270, Brazil.ORCID https://orcid.org/0000-0003-4108-8750
Thaís F A PavaniUniversidade Federal de São Paulo-Campus Diadema, Curso de Pós-Graduação em Biologia Química da Unifesp, Rua São Nicolau 210, 2o andar, Centro, Diadema, São Paulo 09972-270, Brazil.
Ana C A MengardaUniversidade Guarulhos, Núcleo de Pesquisa em Doenças Negligenciadas-NPDN, Praça Tereza Cristina 88, Guarulhos 09972-270, Brazil.
Rayssa A CajasUniversidade Guarulhos, Núcleo de Pesquisa em Doenças Negligenciadas-NPDN, Praça Tereza Cristina 88, Guarulhos 09972-270, Brazil.
Thainá R TeixeiraUniversidade Guarulhos, Núcleo de Pesquisa em Doenças Negligenciadas-NPDN, Praça Tereza Cristina 88, Guarulhos 09972-270, Brazil.
Lucas Fukui-SilvaUniversidade Guarulhos, Núcleo de Pesquisa em Doenças Negligenciadas-NPDN, Praça Tereza Cristina 88, Guarulhos 09972-270, Brazil.
Yujie Uli SunCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0021, United States.
Lawrence J LiuCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0021, United States.ORCID https://orcid.org/0000-0003-2811-1274
Dilini K AmarasingheCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0021, United States.
Michael C YoonCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0021, United States.ORCID https://orcid.org/0000-0002-2900-5257
Osvaldo A Santos-FilhoInstituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, Bloco H, Rio de Janeiro 21941-853, Brazil.ORCID https://orcid.org/0000-0001-7407-158X
Josué de MoraesUniversidade Guarulhos, Núcleo de Pesquisa em Doenças Negligenciadas-NPDN, Praça Tereza Cristina 88, Guarulhos 09972-270, Brazil.ORCID https://orcid.org/0000-0003-1766-7031
Conor R CaffreyCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0021, United States.
Daniela G G RandoGrupo de Pesquisas Químico-Farmacêuticas da Unifesp, Department of Pharmaceutical Sciences Rua São Nicolau, Universidade Federal de São Paulo-Campus Diadema, 210, 2o andar, Centro, Diadema, São Paulo 09972-270, Brazil.ORCID https://orcid.org/0000-0002-6586-5107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schistosomiasis is a neglected disease of poverty that affects over 200 million people worldwide and relies on a single drug for therapy. The cathepsin B1 cysteine protease (SmCB1) of

Identifiers

PMID38882094
PMCPMC11170711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.