Evidence map›Paper›PMID 38882030›Full record

ArticleACS polymers Au2024

Amino-Acid-Derived Anionic Polyacrylamides with Tailored Hydrophobicity-Physicochemical Properties and Cellular Interactions.

Jonas De Breuck, Michael Streiber, Michael Ringleb, Dennis Schröder, Natascha Herzog, Ulrich S Schubert, Stefan Zechel, Anja Traeger, Meike N Leiske

Abstract read
In one paragraph

Article in ACS polymers Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Biomacromolecules · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonas De BreuckMacromolecular Chemistry, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.
Michael StreiberLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.
Michael RinglebLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.ORCID https://orcid.org/0000-0002-7320-8529
Dennis SchröderMacromolecular Chemistry, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.
Natascha HerzogMacromolecular Chemistry, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.
Ulrich S SchubertLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.ORCID https://orcid.org/0000-0003-4978-4670
Stefan ZechelLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.
Anja TraegerLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.ORCID https://orcid.org/0000-0001-7734-2293
Meike N LeiskeMacromolecular Chemistry, University of Bayreuth, Universitätsstraße 30, 95447 Bayreuth, Germany.ORCID https://orcid.org/0000-0002-8525-2324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyanions can internalize into cells via endocytosis without any cell disruption and are therefore interesting materials for biomedical applications. In this study, amino-acid-derived polyanions with different alkyl side-chains are synthesized via postpolymerization modification of poly(pentafluorophenyl acrylate), which is synthesized via reversible addition-fragmentation chain-transfer (RAFT) polymerization, to obtain polyanions with tailored hydrophobicity and alkyl branching. The success of the reaction is verified by size-exclusion chromatography, NMR spectroscopy, and infrared spectroscopy. The hydrophobicity, surface charge, and pH dependence are investigated in detail by titrations, high-performance liquid chromatography, and partition coefficient measurements. Remarkably, the determined p

Identifiers

PMID38882030
PMCPMC11177303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.