Evidence map›Paper›PMID 38881898›Full record

ArticleFrontiers in immunology2024

Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation.

Shuhan Chu, Dan Shan, Luling He, Shilin Yang, Yulin Feng, Yifeng Zhang, Jun Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The role of Smoothelin-B in abdominal aortic aneurysm formation.Biochemistry and biophysics reports · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuhan ChuCenter for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Dan ShanDepartment of Cardiovascular Sciences and Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Luling HeCenter for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Shilin YangNational Pharmaceutical Engineering Center (NPEC) for Solid Preparation in Chinese Herbal Medicine, Nanchang, Jiangxi, China.
Yulin FengNational Pharmaceutical Engineering Center (NPEC) for Solid Preparation in Chinese Herbal Medicine, Nanchang, Jiangxi, China.
Yifeng ZhangCenter for Translational Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Jun YuDepartment of Cardiovascular Sciences and Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a degenerative disease characterized by local abnormal dilation of the aorta accompanied by vascular smooth muscle cell (VSMC) dysfunction and chronic inflammation. VSMC dedifferentiation, transdifferentiation, and increased expression of matrix metalloproteinases (MMPs) are essential causes of AAA formation. Previous studies from us and others have shown that Anemoside B4 (AB4), a saponin from

Indexed as

Aortic Aneurysm, AbdominalCell TransdifferentiationInflammationKruppel-Like Factor 4Myocytes, Smooth MuscleSaponinsAngiotensin IIAnimalsDisease Models, AnimalHumansMacrophagesMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularAngiotensin IIKlf4 protein, mouseKruppel-Like Factor 4Saponinsabdominal aortic aneurysmAnemoside B4transdifferentiationvascular inflammationvascular smooth muscle cell

Identifiers

PMID38881898
PMCPMC11176519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.