Evidence map›Paper›PMID 38881542›Full record

ArticleContemporary clinical trials communications2024

Sevoflurane multiple Wash In/Wash Out at the end of anesthesia to reduce agitation: A multicenter double-blind randomized controlled trial.

Giovanni Landoni, Valery V Likhvantsev, Levan B Berikashvili, Andrey G Yavorovsky, Pavel S Bagdasarov, Anastasia V Smirnova, Tatiana S Serkova, Valery V Subbotin, Kristina K Kadantseva, Alexey M Ovezov and 12 more

Abstract read
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In one paragraph

Article in Contemporary clinical trials communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Giovanni LandoniDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Italy.
Valery V LikhvantsevFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Levan B BerikashviliFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Andrey G YavorovskyFirst University Clinical Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Pavel S BagdasarovFirst University Clinical Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Anastasia V SmirnovaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Tatiana S SerkovaFirst University Clinical Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Valery V SubbotinA. Loginov Moscow Scientific Clinical Center, Moscow, Russia.
Kristina K KadantsevaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Alexey M OvezovM. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia.
Mikhail Ya YadgarovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Alexey A YakovlevFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Andrea LamacchiaDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Italy.
Lorenzo GalloDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Italy.
Nadezhda D GrachevaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Pavel V RyzhkovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.
Rachele ZilocchiDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Italy.
Jessica De VecchiDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Italy.
Maksim A AleinikovFirst University Clinical Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Pavel S MayukFirst University Clinical Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Alina A PivovarovaM. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia.
Maria M ShemetovaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative agitation is common after non-cardiac surgery. It is associated with postoperative delirium and cognitive dysfunction, leading to prolonged hospital stay and delayed social readjustment. Prevention and treatment strategies are lacking. We assessed the efficacy of a novel approach, the Wash In/Wash Out procedure, in reducing post-anesthetic agitation. Methods: This multicenter, parallel-group, double-blind randomized controlled trial is enrolling 200 patients undergoing open abdominal surgery. Participants are randomly assigned to either a control group receiving standard recovery methods or an investigational group undergoing the Wash In/Wash Out procedure. In the Wash In/Wash Out procedure group, sevoflurane is stopped and then promptly restarted when the patient shows the first signs of awakening to achieve an end-tidal concentration of 1 minimum alveolar concentration (MAC) for 5 min. This stop-and-restart cycle is performed three times. The trial's primary outcome is the rate of postoperative agitation. Secondary outcomes include rate of postoperative delirium and cognitive dysfunction, postoperative nausea and vomiting, and length of intensive care and hospital stay. Discussion: The OPERA trial investigates the effect of the Wash In/Wash Out procedure to reduce post-anesthetic agitation in non-cardiac surgery. This study could offer a significant contribution to improving patient outcomes and optimizing recovery protocols in surgical settings.

Indexed as

AnesthesiaNon-cardiac surgeryPostoperative agitationRandomized controlled trialWash in/wash out procedure

Identifiers

PMID38881542
PMCPMC11176941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.