Evidence map›Paper›PMID 38881463›Full record

ArticleHypertension (Dallas, Tex. : 1979)2024

Projected Impact of Nonpharmacologic Management of Stage 1 Hypertension Among Lower-Risk US Adults.

Kendra D Sims, Pengxiao Carol Wei, Joanne M Penko, Susan Hennessy, Pamela G Coxson, Nita H Mukand, Brandon K Bellows, Dhruv S Kazi, Yiyi Zhang, Ross Boylan and 2 more

Abstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kendra D SimsDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).ORCID 0000-0002-6740-3002
Pengxiao Carol WeiDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).ORCID 0000-0002-1045-7261
Joanne M PenkoDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).
Susan HennessyDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).
Pamela G CoxsonDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).
Nita H MukandDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).ORCID 0000-0001-8467-5731
Brandon K BellowsDepartment of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, NY (B.K.B., Y.Z., A.E.M.).ORCID 0000-0003-1395-6047
Dhruv S KaziRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA (D.S.K.).ORCID 0000-0002-9510-2979
Yiyi ZhangDepartment of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, NY (B.K.B., Y.Z., A.E.M.).ORCID 0000-0002-8663-5001
Ross BoylanDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).
Andrew E MoranDepartment of Medicine, Division of General Medicine, Columbia University Irving Medical Center, New York, NY (B.K.B., Y.Z., A.E.M.).ORCID 0000-0003-3554-0085
Kirsten Bibbins-DomingoDepartment of Epidemiology and Biostatistics, University of California San Francisco (K.D.S., P.C.W., J.M.P., S.H., P.G.C., N.H.M., R.B., K.B.D.).ORCID 0000-0002-8962-0622

Funding

Translational Epidemiology - Training for Research on Aging and Chronic diseaseT32AG049663 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Rose Mayeda, Mark J Pletcher · 2016 to 2026
$5.8M
Improving Blood Pressure Screening and Treatment Strategies in Young AdultsR01HL158790 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI AN, JAEJIN, ZHANG, YIYI · 2021 to 2025
$3.5M
Model Based Approach to Improving Hypertension Control in PopulationsR01HL130500 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MORAN, ANDREW EDWARD · 2016 to 2019
$2.4M
Comparing the value of intensive systolic blood pressure treatment implementation strategiesK01HL140170 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BELLOWS, BRANDON K · 2018 to 2022
$709k
Community Empowerment, Vascular Risk, and ADRD Disparities: Translating Research to Public PolicyK99AG083121 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SIMS, KENDRA D · 2023 to 2024
$243k
NHLBI NIH HHS K01 HL140170NHLBI NIH HHS R01 HL130500NHLBI NIH HHS R01 HL158790NIA NIH HHS K99 AG083121NIA NIH HHS T32 AG049663
6 · The paper itself

Abstract

backgroundThe 2017 American College of Cardiology/American Heart Association blood pressure guideline classified 31 million US adults as having stage 1 hypertension and recommended clinicians provide counseling on behavioral change to the low-risk portion of this group. However, nationwide reductions in cardiovascular disease (CVD) and associated health care expenditures achievable by nonpharmacologic therapy remain unquantified.

methodsWe simulated interventions on a target population of US adults aged 35 to 64 years, identified from the 2015-2018 National Health and Nutrition Examination Survey, with low-risk stage 1 systolic hypertension: that is, untreated systolic blood pressure 130 to 139 mm Hg with diastolic BP <90 mm Hg; no history of CVD, diabetes, or chronic kidney disease; and a low 10-year risk of CVD. We used meta-analyses and trials to estimate the effects of population-level behavior modification on systolic blood pressure. We assessed the extent to which restricting intervention to those in regular contact with clinicians might prevent the delivery of nonpharmacologic therapy.

resultsControlling systolic blood pressure to <130 mm Hg among the 8.8 million low-risk US adults with stage 1 hypertension could prevent 26 100 CVD events, avoid 2900 deaths, and save $1.7 billion in total direct health care costs over 10 years. Adoption of the Dietary Approaches to Stop Hypertension diet could prevent 28 000 CVD events. Other nonpharmacologic interventions could avert between 3800 and 19 500 CVD events. However, only 51% of men and 75% of women regularly interacted with clinicians for counseling opportunities.

conclusionsAmong low-risk adults with stage 1 hypertension, substantial benefits to cardiovascular health could be achieved through public policy that promotes the adoption of nonpharmacologic therapy.

Indexed as

HypertensionAdultBlood PressureCardiovascular DiseasesFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesAmerican Heart Associationcardiovascular diseaseshealth care costshypertensionpublic policy

Identifiers

PMID38881463
PMCPMC11254541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.