ArticleUltrasonography (Seoul, Korea)2024
Ultrasonographic features of the skin and subcutis: correlations with the severity of breast cancer-related lymphedema.
Article in Ultrasonography (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- [Research progress on the application of ultrasound technology in the diagnosis and treatment of lymphedema].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- A Retrospective Analysis of Correlations Between Shoulder Impairment and Ultrasound Lymphedema Evaluation in Breast Cancer Patients: Preliminary Results.Biomedicines · 2026Article
- Layer-Specific Assessment of Dermal Thickness and Stiffness Using Shear Wave Elastography in Gynecologic Cancer-Related Lower-Limb Lymphedema: An Exploratory Cross-Sectional Study.International journal of general medicine · 2026Article
- High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema.Biomedicines · 2025Article
- Ultrasonography of the Fasciae and Common Pathologies: The Game Changer.Diagnostics (Basel, Switzerland) · 2025Review
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3 authors.
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Abstract
purposeAssessing the severity of breast cancer-related lymphedema (BCRL) requires various clinical tools, yet no standardized methodology is available. Ultrasonography shows promise for diagnosing lymphedema and evaluating its severity. This study explored the clinical utility of ultrasonography in patients with BCRL.
methodsIn this retrospective cross-sectional study, patients with unilateral BCRL were examined. The analyzed data included demographics, lymphedema location, International Society of Lymphology (ISL) stage, surgical history, treatment regimens, and arm circumference. Skin, subcutis, and muscle thicknesses were assessed ultrasonographically at predetermined sites, and the percentage of excess thickness was calculated. Multivariate logistic regression analysis was employed to identify associations between ultrasonographic measurements and advanced lymphedema (ISL 2 or 3). The Lymphedema Quality of Life arm questionnaire was used to evaluate patient-reported outcomes regarding lymphedema and their correlations with ultrasonographic findings.
resultsAmong 118 patients, 71 were classified as ISL 0-1 and 47 as ISL 2-3. Patients with advanced lymphedema were older, had higher nodal stages, underwent more axillary lymph node dissections, and had higher rates of dominant-arm lymphedema. Multivariate logistic regression revealed significant associations of greater skin thickness (adjusted odds ratio [OR], 4.634; 95% confidence interval [CI], 1.233 to 17.419), subcutis thickness (adjusted OR, 7.741; 95% CI, 1.649 to 36.347), and subcutis echogenicity (adjusted OR, 4.860; 95% CI, 1.517 to 15.566) with advanced lymphedema. Furthermore, greater skin thickness (P=0.016) and subcutis echogenicity (P=0.023) were correlated with appearance-related discomfort.
conclusionUltrasonographic measurements were significantly associated with advanced lymphedema in BCRL. Ultrasonography represents a valuable diagnostic and severity assessment tool for lymphedema.
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