Evidence map›Paper›PMID 38881045›Full record

ArticleAmerican journal of epidemiology2024

The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods.

Andrew M South, Victoria C Giammattei, Kiri W Bagley, Christine Y Bakhoum, William H Beasley, Morgan B Bily, Shupti Biswas, Aaron M Bridges, Rushelle L Byfield, Jessica Fallon Campbell and 38 more

Abstract readMulticenter Study
In one paragraph

Article in American journal of epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Andrew M SouthSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.ORCID 0000-0002-3204-4142
Victoria C GiammatteiSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Kiri W BagleySection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Christine Y BakhoumSection of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06519, United States.
William H BeasleyDevelopmental and Behavioral Pediatrics, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Morgan B BilyDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States.
Shupti BiswasDepartment of Pediatrics, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New Hyde Park, NY 11040, United States.
Aaron M BridgesCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Rushelle L ByfieldDivision of Nephrology and Hypertension, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, United States.
Jessica Fallon CampbellDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States.
Rahul ChanchlaniDivision of Nephrology, Department of Pediatrics, McMaster University, Hamilton, ON L8N 1H4, Canada.
Ashton ChenSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Lucy D'Agostino McGowanDepartment of Statistical Sciences, Wake Forest University, Winston Salem, NC 27157, United States.
Stephen M DownsDepartment of Pediatrics-General, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Gina M FergesonDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Jason H GreenbergSection of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06519, United States.
Taylor A Hill-HorowitzDivision of Nephrology, Department of Pediatrics, Cohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11040, United States.
Elizabeth T JensenDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Mahmoud KallashDivision of Nephrology and Hypertension, Department of Pediatrics, Ohio State College of Medicine, Columbus, OH 43205, United States.
Margret KamelDivision of Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, United States.
Stefan G KiesslingDivision of Nephrology, Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY 40506, United States.
David M KlineDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.ORCID 0000-0001-6183-3303
John R LaisureSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Gang LiuDivision of Pediatric Research, Department of Pediatrics, Atrium Health Levine Children's, Charlotte, NC 28207, United States.
Jackson LondereeDivision of Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, United States.
Caroline B LucasSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Sai Sudha MannemuddhuDivision of Pediatric Nephrology, East Tennessee Children's Hospital, University of Tennessee at Knoxville, Knoxville, TN 37916, United States.
Kuo-Rei MaoIS Enterprise Reporting, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, United States.
Jason M MisuracDivision of Nephrology, Dialysis, and Transplantation, Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, United States.
Margaret O MurphyDivision of Nephrology, Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY 40506, United States.
James T NugentSection of Nephrology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06519, United States.
Elizabeth A OnughaDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States.
Ashna PudupakkamDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States.
Kathy M RedmondDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Sandeep RiarDivision of Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, United States.
Christine B SethnaDivision of Nephrology, Department of Pediatrics, Cohen Children's Medical Center, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11040, United States.
Sahar SiddiquiDivision of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, United States.
Ashley L ThumannGeneral and Community Pediatrics, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Stephen R UssYale Center for Clinical Investigation, Yale University School of Medicine, New Haven, CT 06519, United States.
Carol L VincentSection of Nephrology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Irina V VivianoCenter for Artificial Intelligence Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Michael J WalshSection of Cardiology, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States.
Blanche D WhiteDivision of Nephrology and Hypertension, Department of Pediatrics, Atrium Health Levine Children's, Charlotte, NC 28203, United States.
Robert P WoronieckiDivision of Nephrology, Department of Pediatrics, Stony Brook Medicine, Stony Brook, NY 11794, United States.
Michael WuMcMaster University School of Medicine, Hamilton, ON L8N 1H4, Canada.
Ikuyo YamaguchiDepartment of Pediatrics, Division of Nephrology, University of Oklahoma College of Medicine, Oklahoma City, OK 73104, United States.
Emily YunDivision of Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, United States.
Donald J WeaverDivision of Nephrology and Hypertension, Department of Pediatrics, Atrium Health Levine Children's, Charlotte, NC 28203, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born PretermR01HL146818 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHAPPELL, MARK C, SHALTOUT, HOSSAM · 2019 to 2023
$4.0M
Kids: Nocturnal Investigation into Glomerular Disease, Hypertension, and Transcriptomics (kNIGHT)R01HL162912 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Christine B Sethna · 2023 to 2026
$2.9M
J. NRSA Training Core (TL1)TL1TR003136 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOOZE, JANET A. · 2019 to 2023
$2.1M
A Pilot Study of Transcutaneous Auricular Vagus Nerve Stimulation for the Treatment of Idiopathic Nephrotic Syndrome in ChildrenR01DK131091 · NIDDK · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SETHNA, CHRISTINE B · 2022 to 2024
$1.0M
The role of angiotensin-(1-7) in hypertension and hypertension-induced heart and kidney damageK23HL148394 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOUTH, ANDREW MICHAEL · 2020 to 2024
$783k
Canadian Institutes of Health Research and Kidney Foundation of CanadaNational Institutes of Health (NIH) National Center for Advancing Translational Sciences UL1TR001420NCATS NIH HHS TL1 TR003136NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL148394NHLBI NIH HHS L40 HL148910NHLBI NIH HHS R01 HL146818NHLBI NIH HHS R01 HL162912NHLBI NIH HHS R01-HL162912NIDDK NIH HHS R01 DK131091NIH National Heart, Lung, and Blood Institute K23-HL148394NIH National Institute of Diabetes and Digestive and Kidney Diseases R01-DK131091Wake Forest University School of Medicine Clinical and Translational Science Institute and Atrium Health Translational Research Initiative Joint Pilot Project Award
6 · The paper itself

Abstract

Despite increasing prevalence of hypertension in youth and high adult cardiovascular mortality rates, the long-term consequences of youth-onset hypertension remain unknown. This is due to limitations of prior research, such as small sample sizes, reliance on manual record review, and limited analytic methods, that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite, retrospective registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases, 10th Revision (ICD-10) code-defined hypertension disorder on or after January 1, 2015, and age < 19 years. We exclude patients with ICD-10 code-defined pregnancy, kidney failure on dialysis, or kidney transplantation. Data include demographics, anthropomorphics, US Census Bureau tract, histories, blood pressure, ICD-10 codes, medications, laboratory and imaging results, and ambulatory blood pressure. SUPERHERO leverages expertise in epidemiology, statistics, clinical care, and biomedical informatics to create the largest and most diverse registry of youth with newly diagnosed hypertension disorders. SUPERHERO's goals are to reduce CVD burden across the life course and establish gold-standard biomedical informatics methods for youth with hypertension disorders.

Indexed as

HypertensionRegistriesAdolescentChildChild, PreschoolElectronic Health RecordsFemaleHumansInternational Classification of DiseasesMalePrevalenceRetrospective StudiesUnited Statesbiomedical informaticsblood pressurecardiovascular healthcausal inferencechild healthelectronic health recordlife courseyouth

Identifiers

PMID38881045
PMCPMC11637526

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.