Evidence map›Paper›PMID 38880861›Full record

ArticleMolecular and cellular biochemistry2025

Angiopoietin-like protein 2 inhibits thrombus formation.

Tiantian Zhang, Mingliang Zhang, Lingyu Guo, Dongsheng Liu, Kandi Zhang, Changlong Bi, Peng Zhang, Jin Wang, Yuqi Fan, Qing He and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tiantian Zhang *Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Mingliang Zhang *Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Lingyu Guo *Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Dongsheng LiuDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Kandi ZhangDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Changlong BiDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Peng ZhangDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Jin WangDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Yuqi FanDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Qing HeDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Alex C Y ChangDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Junfeng ZhangDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. jfzhang_dr@163.com.

Funding

Biological sample Bank project of The Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine YBKA202206Chinese National Natural Science Foundation Grant 81970289Chinese National Natural Science Foundation Grant 82300362Clinical Research Program of 9th People's Hospital, Shanghai Jiao Tong University School of Medicine JYLJ202014Cross Research Fund project of The Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine JYJC202127Experimental animal research project of Shanghai Science and Technology Innovation Action Plan 22140901200SHIPM-mu fund from Shanghai Institute of Precision Medicine, Ninth People`s Hospital Shanghai Jiao Tong University School of Medicine JC202005
6 · The paper itself

Abstract

Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation in vitro through binding with immunoglobulin-like receptor B, an immunoglobulin superfamily receptor. However, the mechanism by which it regulates platelet function in vivo remains unclear. In this study, we investigated the role of ANGPTL2 during thrombosis in relationship with ST-segment elevation myocardial infarction (STEMI) with spontaneous recanalization (SR). In a cohort of 276 male and female patients, we measured plasma ANGPTL2 protein levels. Using male Angptl2-knockout and wild-type mice, we examined the inhibitory effect of Angptl2 on thrombosis and platelet activation both in vivo and ex vivo. We found that plasma and platelet ANGPTL2 levels were elevated in patients with STEMI with SR compared to those in non-SR (NSR) patients, and was an independent predictor of SR. Angptl2 deficiency accelerated mesenteric artery thrombosis induced by FeCl

Indexed as

Angiopoietin-like ProteinsBlood PlateletsST Elevation Myocardial InfarctionThrombosisAngiopoietin-Like Protein 2AnimalsFemaleHumansMaleMiceMice, KnockoutMiddle AgedPlatelet ActivationPlatelet AggregationAngiopoietin-Like Protein 2Angiopoietin-like ProteinsANGPTL2 protein, humanAngptl2 protein, mouseAngiopoietin-like protein 2ITAM (immunoreceptor tyrosine-based activation motif)ITIM (immunoreceptor tyrosine-based inhibition motif)PlateletThrombosis

Identifiers

PMID38880861
PMCPMC11835982

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.