ArticleCerebral cortex (New York, N.Y. : 1991)2024
Leveraging the adolescent brain cognitive development study to improve behavioral prediction from neuroimaging in smaller replication samples.
Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Feature selection leads to divergent neurobiological interpretations of brain-based machine learning biomarkers.Nature human behaviour · 2026Article
- Task and Resting-State Functional Magnetic Resonance Imaging Modeling of Brain-Behavior Relationships in Developmental Cohorts.Biological psychiatry · 2026Review
- Spontaneous brain regional dynamics contribute to generalizable brain-behaviour associations.Nature human behaviour · 2026Article
- Overlooked features lead to divergent neurobiological interpretations of brain-based machine learning biomarkers.bioRxiv : the preprint server for biology · 2025Article
- Article
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.Molecular psychiatry · 2025Article
- Clinical profile impacts the replicability of multivariate brain-behavioural associations.bioRxiv : the preprint server for biology · 2025Article
- Improving predictability, reliability, and generalizability of brain-wide associations for cognitive abilities via multimodal stacking.PNAS nexus · 2025Article
- Review
- Time Persistence of the FMRI Resting-State Functional Brain Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Review
- External validation of machine learning models-registered models and adaptive sample splitting.GigaScience · 2025Article
- Multiscale brain modeling: bridging microscopic and macroscopic brain dynamics for clinical and technological applications.Frontiers in cellular neuroscience · 2025Review
- Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.Developmental cognitive neuroscience · 2024Review
- Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders.medRxiv : the preprint server for health sciences · 2024Article
- Quality over quantity: powering neuroimaging samples in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Connectome-based fingerprinting: reproducibility, precision, and behavioral prediction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Multivariate analysis of multimodal brain structure predicts individual differences in risk and intertemporal preference.bioRxiv : the preprint server for biology · 2024Article
- Brain imaging studies of emotional well-being: a scoping review.Frontiers in psychology · 2023Article
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9 authors.
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Abstract
Neuroimaging is a popular method to map brain structural and functional patterns to complex human traits. Recently published observations cast doubt upon these prospects, particularly for prediction of cognitive traits from structural and resting state functional magnetic resonance imaging (MRI). We leverage baseline data from thousands of children in the Adolescent Brain Cognitive DevelopmentSM Study to inform the replication sample size required with univariate and multivariate methods across different imaging modalities to detect reproducible brain-behavior associations. We demonstrate that by applying multivariate methods to high-dimensional brain imaging data, we can capture lower dimensional patterns of structural and functional brain architecture that correlate robustly with cognitive phenotypes and are reproducible with only 41 individuals in the replication sample for working memory-related functional MRI, and ~ 100 subjects for structural and resting state MRI. Even with 100 random re-samplings of 100 subjects in discovery, prediction can be adequately powered with 66 subjects in replication for multivariate prediction of cognition with working memory task functional MRI. These results point to an important role for neuroimaging in translational neurodevelopmental research and showcase how findings in large samples can inform reproducible brain-behavior associations in small sample sizes that are at the heart of many research programs and grants.
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