ReviewSeminars in radiation oncology2024
Navigating the Critical Translational Questions for Implementing FLASH in the Clinic.
Review in Seminars in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Noninvasive Reversible Software-Based Electron FLASH Irradiation Configuration of a Linear Accelerator in Clinical Use.International journal of radiation oncology, biology, physics · 2026Article
- Commissioning and Validation of a Synchrocyclotron - Based Ultra-High-Dose-Rate Beamline for FLASH.International journal of particle therapy · 2026Article
- For ultra-high dose rate carbon-ion irradiation, comparable beam parameters induce the equivalent cell sparing (FLASH) effect.Journal of radiation research · 2026Article
- FLASH radiotherapy preserves hepatic function and maintains metabolic homeostasis in a murine breast cancer model: an experimental preclinical study.Radiation oncology (London, England) · 2026Article
- Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose-per-pulse (FLASH) irradiation.Medical physics · 2026Article
- FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia.bioRxiv : the preprint server for biology · 2026Article
- Article
- Small dose monitor based on silicon-carbide diodes for FLASH radiotherapy.Medical physics · 2026Article
- Spread-Out Bragg Peak FLASH Radiotherapy for Head and Neck Reirradiation: A Treatment Planning Study.International journal of particle therapy · 2026Article
- Systematic analysis of biological endpoint variability and implications for quantitative modeling of the FLASH sparing effect.Physics and imaging in radiation oncology · 2026Review
- Mechanisms, challenges and opportunities for FLASH radiotherapy in cancer.Nature reviews. Cancer · 2026Review
- Microenvironmental remodeling in FLASH radiotherapy.Frontiers in cell and developmental biology · 2026Review
- The potential and risks of FLASH radiotherapy in pediatric patients.Neuro-oncology pediatrics · 2026Review
- Developing oxidative stress-responsive neuroprotective nanotheranostic agents for the image-guided treatment of radiotherapy-induced brain injury.Nanotheranostics · 2026Article
- Physicochemical indication of the FLASH effect from shoot-through proton pencil beam scanning parameters delivered under ultra-high dose rates.Physics in medicine and biology · 2025Article
- Beam intensity and stability control on a modified clinical linear accelerator for FLASH irradiation.Physics in medicine and biology · 2025Article
- Fixation method influences FLASH skin sparing in an in vivo leg model.Acta oncologica (Stockholm, Sweden) · 2025Article
- Discordance in Acute Gastrointestinal Toxicity between Synchrotron-Based Proton and Linac-based Electron Ultra-High Dose Rate Irradiation.International journal of radiation oncology, biology, physics · 2025Article
- Monte Carlo simulation of a novel medical linac concept for highly conformal x-ray FLASH cancer radiotherapy.Scientific reports · 2025Article
- Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.Clinical and translational radiation oncology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The "FLASH effect" is an increased therapeutic index, that is, reduced normal tissue toxicity for a given degree of anti-cancer efficacy, produced by ultra-rapid irradiation delivered on time scales orders of magnitude shorter than currently conventional in the clinic for the same doses. This phenomenon has been observed in numerous preclinical in vivo tumor and normal tissue models. While the underlying biological mechanism(s) remain to be elucidated, a path to clinical implementation of FLASH can be paved by addressing several critical translational questions. Technological questions pertinent to each beam type (eg, electron, proton, photon) also dictate the logical progression of experimentation required to move forward in safe and decisive clinical trials. Here we review the available preclinical data pertaining to these questions and how they may inform strategies for FLASH cancer therapy clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.