Evidence map›Paper›PMID 38880428›Full record

ArticleOsteoarthritis and cartilage2024

Diminished vibration perception and greater pressure pain sensitivity are associated with worse knee osteoarthritis outcomes across sex and race.

Chris Y Lane, Louise M Thoma, Carolina Alvarez, Deborah L Givens, Amanda E Nelson, Adam P Goode, Kharma C Foucher, Yvonne M Golightly

Abstract read
In one paragraph

Article in Osteoarthritis and cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chris Y LaneDepartment of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: chris_lane@med.unc.edu.
Louise M ThomaDepartment of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: louise_thoma@med.unc.edu.
Carolina AlvarezThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: alvarec@live.unc.edu.
Deborah L GivensDepartment of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: deborah_givens@med.unc.edu.
Amanda E NelsonThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: amanda_nelson@med.unc.edu.
Adam P GoodeDepartment of Orthopedic Surgery, Duke University, Durham, NC, United States. Electronic address: adam.goode@duke.edu.
Kharma C FoucherDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, United States. Electronic address: kfouch1@uic.edu.
Yvonne M GolightlyCollege of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: ygolightly@unmc.edu.

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
NIAMS Multidisciplinary Clinical Research CenterP60AR064166 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHWARTZ, TODD A · 2013 to 2017
$5.8M
NCCDPHP CDC HHS U01 DP003206NCCDPHP CDC HHS U01 DP006266NIAMS NIH HHS P30 AR072580NIAMS NIH HHS P60 AR064166
6 · The paper itself

Abstract

objectiveTo examine associations of vibration sensitivity and pressure pain sensitivity with knee osteoarthritis (OA) outcomes across sex and race, which may relate to known sex and race disparities in clinical outcomes.

designData were from the 2013-2015 visit of the Johnston County Osteoarthritis Project. Exposures were vibration perception threshold (VPT) measured at the bilateral medial femoral condyle (MFC) and first metatarsophalangeal joint (MTP), and pressure pain threshold (PPT) measured at the bilateral upper trapezius. Outcomes were knee pain severity and presence of knee symptoms, radiographic knee OA, and symptomatic knee OA in each knee. Cross-sectional associations of the exposures with the outcomes were examined using logistic regression models, overall and separately by sex and race.

resultsIn the VPT and PPT analyses, 851 and 862 participants (mean age 71 years, 68% female, 33% Black, body mass index 31 kg/m

conclusionsDiminished vibration perception and greater pressure pain sensitivity were cross-sectionally associated with worse knee OA outcomes. Despite differences in VPT and PPT among females and males and Black and White adults, associations with knee OA outcomes did not differ by sex or race, suggesting neurophysiological differences do not relate to established disparities.

Indexed as

Osteoarthritis, KneePain ThresholdPressureVibrationAgedArthralgiaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPain MeasurementSeverity of Illness IndexSex FactorsKneeOsteoarthritisPressure pain sensitivityRaceSexVibration sensitivity

Identifiers

PMID38880428
PMCPMC12043336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.