Evidence map›Paper›PMID 38880194›Full record

ArticleJournal of molecular and cellular cardiology2024

Sex-dependent phosphorylation of Argonaute 2 reduces the mitochondrial translocation of miR-181c and induces cardioprotection in females.

Diego Quiroga, Barbara Roman, Marwan Salih, William N Daccarett-Bojanini, Haley Garbus, Obialunanma V Ebenebe, Jeffrey M Dodd-O, Brian O'Rourke, Mark Kohr, Samarjit Das

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diego QuirogaDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, United States of America.
Barbara RomanDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, United States of America.
Marwan SalihDepartment of Pathology, Johns Hopkins University, Baltimore, MD 21205, United States of America.
William N Daccarett-BojaniniDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, United States of America.
Haley GarbusDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States of America.
Obialunanma V EbenebeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States of America.
Jeffrey M Dodd-ODepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, United States of America.
Brian O'RourkeDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, United States of America.
Mark KohrDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States of America.
Samarjit DasDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, United States of America; Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, United States of America. Electronic address: sdas11@jhmi.edu.

Funding

Sex differences in the impact of frailty on vaccine-induced immune responses in community-dwelling older adultsU54AG062333 · NIA · JOHNS HOPKINS UNIVERSITY · PI KLEIN, SABRA L. · 2018 to 2022
$8.9M
Exosome-based Non-traditional Technologies Towards Multi-Parametric andIntegrated Approaches for SARS-CoV-2U18TR003780 · NCATS · JOHNS HOPKINS UNIVERSITY · PI DAS, SAMARJIT · 2021 to 2022
$2.0M
Role of formaldehyde, formate and one-carbon metabolism in the female heartR21HL157800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2021 to 2022
$450k
Sex Differences in Endogenous Formaldehyde Production and One-Carbon Metabolism: Potential Links to CardioprotectionF31HL165820 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GARBUS, HALEY CAITLIN · 2022 to 2023
$74k
American Heart Association-American Stroke Association 23DIVSUP1057308American Heart Association-American Stroke Association 970850NCATS NIH HHS U18 TR003780NHLBI NIH HHS F31 HL165820NHLBI NIH HHS R21 HL157800NIA NIH HHS U54 AG062333
6 · The paper itself

Abstract

Obesity-induced cardiac dysfunction is growing at an alarming rate, showing a dramatic increase in global prevalence. Mitochondrial translocation of miR-181c in cardiomyocytes results in excessive reactive oxygen species (ROS) production during obesity. ROS causes Sp1, a transcription factor for MICU1, to be degraded via post-translational modification. The subsequent decrease in MICU1 expression causes mitochondrial Ca

Indexed as

Argonaute ProteinsMicroRNAsMyocytes, CardiacReactive Oxygen SpeciesAnimalsCalciumCalcium-Binding ProteinsCation Transport ProteinsFemaleHumansInsulinMaleMiceMitochondriaMitochondria, HeartMitochondrial Membrane Transport ProteinsAgo2 protein, mouseArgonaute ProteinsCalciumCalcium-Binding ProteinsCation Transport ProteinsInsulinMicroRNAsMICU1 protein, mousemirn181 microRNA, mouseMitochondrial Membrane Transport ProteinsReactive Oxygen SpeciesRNA-Induced Silencing ComplexSp1 Transcription FactorGender differencesHeartmiR-181cMitochondrial microRNAObesity

Identifiers

PMID38880194
PMCPMC11345856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.