Evidence map›Paper›PMID 38879913›Full record

ArticleInternational journal of hygiene and environmental health2024

Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study.

Yu Ni, Adam A Szpiro, Christine T Loftus, Tomomi Workman, Alexis Sullivan, Erin R Wallace, Anne M Riederer, Drew B Day, Laura E Murphy, Ruby H N Nguyen and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yu NiDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Division of Epidemiology and Biostatistics, School of Public Health, College of Health and Human Services, San Diego State University, San Diego, CA, USA. Electronic address: yni5@sdsu.edu.
Adam A SzpiroDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Christine T LoftusDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Tomomi WorkmanDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Alexis SullivanDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Erin R WallaceDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Anne M RiedererDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Drew B DayCenter for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, USA.
Laura E MurphyDepartment of Psychiatry, University of Tennessee Health Science Center, Memphis, TN, USA.
Ruby H N NguyenDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minnesota, USA.
Sheela SathyanarayanaDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA.
Qi ZhaoDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Daniel A EnquobahrieDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Christopher SimpsonDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Shaikh I AhmadDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jessica A ArizagaDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Brent R CollettCenter for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Karen J DerefinkoDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Pharmacology, Addiction Science, and Toxicology, University of Tennessee Health Science Center, Memphis, TN, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Albany, NY, USA.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Catherine J KarrDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA, USA.

Funding

The NYU Children’s Health & Environment Study: an ECHO CohortUH3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Akhgar Ghassabian, Leonardo Trasande · 2018 to 2026
$59.5M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
The NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUG3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2016 to 2017
$5.1M
The Infant Development and the Environmental Study (TIDES)R01ES016863 · NIEHS · UNIVERSITY OF ROCHESTER · PI SWAN, SHANNA H · 2009 to 2014
$4.0M
ECHO in Agricultural Washington and Rural Environments (ECHO AWARE)UG3OD035528 · OD · UNIVERSITY OF WASHINGTON · PI KARR, CATHERINE J · 2023 to 2024
$2.4M
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES016863NIH HHS UG3 OD023271NIH HHS UG3 OD023305NIH HHS UG3 OD035528NIH HHS UH3 OD023271NIH HHS UH3 OD023305
6 · The paper itself

Abstract

backgroundExecutive functions develop rapidly in childhood, enabling problem-solving, focused attention, and planning. Exposures to environmental toxicants in pregnancy may impair healthy executive function development in children. There is increasing concern regarding polycyclic aromatic hydrocarbons (PAHs) given their ability to transfer across the placenta and the fetal blood-brain barrier, yet evidence from epidemiological studies is limited.

methodsWe examined associations between prenatal PAH exposure and executive functions in 814 children of non-smoking mothers from two U.S. cohorts in the ECHO-PATHWAYS Consortium. Seven mono-hydroxylated PAH metabolites were measured in mid-pregnancy urine and analyzed individually and as mixtures. Three executive function domains were measured at age 8-9: cognitive flexibility, working memory, and inhibitory control. A composite score quantifying overall performance was further calculated. We fitted linear regressions adjusted for socio-demographics, maternal health behaviors, and psychological measures, and examined modification by child sex and stressful life events in pregnancy. Bayesian kernel machine regression was performed to estimate the interactive and overall effects of the PAH mixture.

resultsThe results from primary analysis of linear regressions were generally null, and no modification by child sex or maternal stress was indicated. Mixture analyses suggested several pairwise interactions between individual PAH metabolites in varied directions on working memory, particularly interactions between 2/3/9-FLUO and other PAH metabolites, but no overall or individual effects were evident.

conclusionWe conducted a novel exploration of PAH-executive functions association in a large, combined sample from two cohorts. Although findings were predominantly null, the study carries important implications for future research and contributes to evolving science regarding developmental origins of diseases.

Indexed as

Executive FunctionPolycyclic Aromatic HydrocarbonsPrenatal Exposure Delayed EffectsAdultChildCohort StudiesEnvironmental PollutantsFemaleHumansMaleMaternal ExposureMemory, Short-TermPregnancyEnvironmental PollutantsPolycyclic Aromatic HydrocarbonsExecutive functionsMaternal psychosocial stressMixture analysisPolycyclic aromatic hydrocarbons

Identifiers

PMID38879913
PMCPMC11896739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.