Evidence map›Paper›PMID 38879905›Full record

ArticleEpilepsy research2024

Rat strain differences in seizure frequency and hilar neuron loss after systemic treatment with pilocarpine.

Kristina Junghans, Megan Wyeth, Paul S Buckmaster

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristina JunghansDepartments of Comparative Medicine, Stanford University, 3172 Porter Drive, Palo Alto, CA 94304-5475, USA.
Megan WyethDepartments of Comparative Medicine, Stanford University, 3172 Porter Drive, Palo Alto, CA 94304-5475, USA. Electronic address: mwyeth@stanford.edu.
Paul S BuckmasterDepartments of Comparative Medicine, Stanford University, 3172 Porter Drive, Palo Alto, CA 94304-5475, USA; Departments of Neurology & Neurological Sciences, Stanford University, 3172 Porter Drive, Palo Alto, CA 94304-5475, USA.

Funding

Interneuron-based mechanisms of temporal lobe epilepsyR01NS107290 · NINDS · STANFORD UNIVERSITY · PI BUCKMASTER, PAUL S. · 2019 to 2023
$2.9M
Research Opportunities in Comparative MedicineT35OD010989 · OD · STANFORD UNIVERSITY · PI BUCKMASTER, PAUL S. · 2012 to 2022
$565k
NIH HHS T35 OD010989NINDS NIH HHS R01 NS107290
6 · The paper itself

Abstract

At least 3 months after systemic treatment with pilocarpine to induce status epilepticus, Long-Evans and Sprague-Dawley rats were video-EEG monitored for seizures continuously for 1 month. Rats were then perfused, hippocampi were processed for Nissl staining, and hilar neurons were quantified. Seizure frequency in Long-Evans rats was 1/10th of that in Sprague-Dawley rats, and more variable. Hilar neuron loss was also less severe in Long-Evans rats. However, there was no correlation between hilar neuron loss and seizure frequency in either strain. The low and variable seizure frequency suggests limited usefulness of pilocarpine-treated Long-Evans rats for some epilepsy experiments.

Indexed as

ElectroencephalographyNeuronsPilocarpineRats, Long-EvansRats, Sprague-DawleySeizuresAnimalsDisease Models, AnimalHippocampusMaleRatsSpecies SpecificityStatus EpilepticusPilocarpineEpilepsyHilusLong-EvansPilocarpineSeizureSprague-Dawley

Identifiers

PMID38879905
PMCPMC11253724

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.