Evidence map›Paper›PMID 38879777›Full record

ArticleCurrent rheumatology reviews2025

Exploring the Relationship between ACE Gene Variants and Systemic Lupus Erythematosus Susceptibility in the Hainan Population through Genetic Association Analysis.

Guiling Lin, Yanping Zhuang, Xuan Zhang, Qi Zhang, Huitao Wu, Wenlu Xu, Zhe Wang, Ziman He, Linglan Su, Xiaokang Jia and 1 more

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Article in Current rheumatology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Guiling LinSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China.
Yanping ZhuangInternational Research Center for Aging and Oncology, Hainan Medical University, Haikou, Hainan, 571199, China.
Xuan ZhangSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China.
Qi ZhangHeilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, China.
Huitao WuHeilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, China.
Wenlu XuSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China.
Zhe WangSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China.
Ziman HeHeilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, China.
Linglan SuHeilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang, 150036, China.
Xiaokang JiaSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China.
Aimin GongSchool of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, 571199, China.

Funding

National Natural Science Foundation of China 82160874,81760840Science and Technology special fund of Hainan Province ZDVP2022SHF278
6 · The paper itself

Abstract

backgroundThe purpose of this study was to determine the association between single nucleotide polymorphisms (SNPs) at the rs4331, rs4341, and rs4351 loci of the angiotensinconverting enzyme (ACE) gene and genetic susceptibility to systemic lupus erythematosus (SLE) in the Hainan population.

methodsThis study involved a total of 428 participants, with 214 individuals diagnosed with SLE and an equal number of healthy controls. The SNaPshot sequencing technique was used to determine the base sequences at the ACE gene rs4331, rs4341, and rs4351 loci in the study subjects. Logistic regression was employed to compare the frequency distribution of genotypes and allele frequencies at each locus between the case group and the control group. HaploView 4.2 software was used to analyze the relationship between haplotypes at each locus and genetic susceptibility to SLE.

resultsThe GG genotype and G allele frequency at the rs4341 locus were higher in the case group compared to the control group. In the rs4341 recessive model, carriers of the GG genotype were more likely to develop SLE compared to carriers of the CG+CC genotype (OR = 1.889, 95% CI: 1.195-2.988, P = 0.006). In the rs4351 overdominant model, carriers of the AC genotype had an increased risk of developing SLE compared to carriers of the AA+CC genotype (OR = 1.514, 95% CI: 1.033-2.219, P = 0.033). The rs4341 and rs4351 loci exhibited linkage disequilibrium, and the CA haplotype (OR = 0.630, 95% CI: 0.481-0.826, P = 0.001) was a protective factor against SLE. The GA haplotype (OR = 2.849, 95% CI: 1.901-4.270, P < 0.01) and the CC haplotype (OR = 2.309, 95% CI: 1.210-4.405, P = 0.009) were risk factors for genetic susceptibility to SLE in the Hainan population.

conclusionThe rs4341 locus of the ACE gene is associated with genetic susceptibility to SLE in the Hainan population.

Indexed as

Genetic Predisposition to DiseaseLupus Erythematosus, SystemicPeptidyl-Dipeptidase AAdultCase-Control StudiesChinaEast Asian PeopleFemaleGene FrequencyGenetic Association StudiesGenotypeHaplotypesHumansMaleMiddle AgedPolymorphism, Single NucleotideACE protein, humanPeptidyl-Dipeptidase AACE genegenetic association.Hainan populationrs4341 locussingle nucleotide polymorphismsystemic lupus erythematosus

Identifiers

PMID38879777

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