Evidence map›Paper›PMID 38879737›Full record

ArticleDigestive diseases and sciences2024

Cinnamaldehyde Regulates the Migration and Apoptosis of Gastric Cancer Cells by Inhibiting the Jak2/Stat3 Pathway.

Yuan-Yuan Geng, Shuo Yang, Zhi-Hao Liu, Si-Yu Wang, Pan Ge

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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yuan-Yuan Geng *Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Shuo Yang *Department of Central Laboratory, Huang Gang Hospital of Traditional Chinese Medicine, Huanggang, 438000, Hubei, China.
Zhi-Hao LiuMedical School, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Si-Yu WangMedical School, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Pan GeDepartment of Pathology, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. gepan@xjtu.edu.cn.ORCID http://orcid.org/0009-0009-5951-0228

Funding

Natural Science Foundation of Hubei Province 2022CFB962Natural Science Foundation of Shaanxi Province 2024JC-YBQN-0771
6 · The paper itself

Abstract

objectiveGastric cancer is a malignant tumor with high morbidity and mortality all around the world. Because of its poor prognosis and low survival rate, the treatment of gastric cancer has received extensive attention. Cinnamaldehyde (CA) is the main single active component of the Chinese herbal medicine cinnamon, which has a variety of pharmacological effects. The inhibitory effect of CA on the growth of some tumor cells has been proven, but its therapeutic effect on gastric cancer has rarely been reported.

methodsThrough network pharmacology, bioinformatics methods, and molecular docking technology, we predicted the interaction targets of CA and gastric cancer. Moreover, we found that apoptosis is an important mode of action of CA on gastric cancer cells. Subsequently, we validated it in gastric cancer cell lines cultured in vitro.

resultsThe results showed that in the presence of CA, the Jak2/Stat3 pathway was inhibited, the ratio of Bcl-2/Bax decreased, and the apoptosis of gastric cancer cells was promoted in a concentration-dependent.

conclusionIn conclusion, CA can promote the apoptosis of gastric cancer cells by inhibiting the activity of the Jak2/Stat3 pathway, which may achieve the effect of treating gastric cancer.

Indexed as

AcroleinApoptosisCell MovementJanus Kinase 2Signal TransductionSTAT3 Transcription FactorStomach NeoplasmsCell Line, TumorHumansMolecular Docking SimulationProto-Oncogene Proteins c-bcl-2AcroleincinnamaldehydeJAK2 protein, humanJanus Kinase 2Proto-Oncogene Proteins c-bcl-2STAT3 protein, humanSTAT3 Transcription FactorCinnamaldehydeGastric cancerJak2Stat3

Identifiers

PMID38879737

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