Evidence map›Paper›PMID 38879717›Full record

ArticleImmunologic research2024

Flagellin conjugated Per a 10 and its T cell peptides attenuate airway inflammation and restore cellular function.

Richa Mishra, Swati Sharma, Naveen Arora

Abstract read
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In one paragraph

Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richa MishraAllergy and Immunology Section, CSIR-Institute of Genomics and Integrative Biology, Mall Road Campus, New Delhi, Delhi, 110007, India.
Swati SharmaAllergy and Immunology Section, CSIR-Institute of Genomics and Integrative Biology, Mall Road Campus, New Delhi, Delhi, 110007, India.
Naveen AroraAllergy and Immunology Section, CSIR-Institute of Genomics and Integrative Biology, Mall Road Campus, New Delhi, Delhi, 110007, India. naveen@igib.res.in.

Funding

Indian Council of Medical Research BMS/Adhoc/ALL/2015-1349/DL/Govt
6 · The paper itself

Abstract

Adjuvants were used to modulate response towards relevant immune cells. The present study aims to investigate FlaA-conjugated Per a 10 and T cell peptides in amelioration of allergic airway disease in mice. Mice given Per a 10 showed allergic features with higher cellular infiltration, IgE, Th-2 cytokines and alarmins. Fusion protein treatment reduced lung inflammation (p < 0.0001) and cellular infiltrates (p < 0.001) with higher IgG2a/IgE indicating resolution of disease. Immunotherapy with FPT1 and FPT3 reduces IL-4, IL-5 and IL-13 levels (p < 0.0001) with a fourfold increase in IFN-γ secretion in BALF. FPT1- and FPT3-treated mice have increased IL-10 and TGF-β levels (p < 0.001) with CD4

Indexed as

CytokinesFlagellinAdjuvants, ImmunologicAnimalsDisease Models, AnimalFemaleImmunoglobulin ELungMiceMice, Inbred BALB CPeptidesRecombinant Fusion ProteinsT-Lymphocytes, RegulatoryAdjuvants, ImmunologicCytokinesFlagellinImmunoglobulin EPeptidesRecombinant Fusion ProteinsAdjuvantsImmunotherapyRegulatory T cellsTight junction proteinsToll-like receptors (TLRs)

Identifiers

PMID38879717

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.