Evidence map›Paper›PMID 38879661›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2024

Sesamol Alleviates Sarcopenia via Activating AKT/mTOR/FoxO1 Signal Pathway in Aged Obese Mice.

Jinxin Yang, Zhipeng Wang, Yan Xie, Yongyan Tang, Yansong Fu, Zhuoya Xu, Jingmiao Chen, Hong Qin

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinxin Yang *Xiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Zhipeng Wang *Xiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Yan XieXiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Yongyan TangXiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Yansong FuXiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Zhuoya XuXiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Jingmiao ChenXiangya School of Public Health, Central South University, Hunan Province, Changsha, China.
Hong QinXiangya School of Public Health, Central South University, Hunan Province, Changsha, China. qinhong@csu.edu.cn.

Funding

National Natural Science Foundation of China 82073556Postgraduate Research and Innovation Project of Central South University 1053320221648Postgraduate Research and Innovation Project of Central South University 1053320222467
6 · The paper itself

Abstract

Sesamol is a major bioactive component extracted from sesame seeds and has various medicinal properties. However, the effects of sesamol on sarcopenia associated with aging and obesity remains unclear. Therefore, the protective effects and underlying mechanisms of sesamol on sarcopenia was evaluated in aged and obese C57BL/6 J male mouse models fed a high fat diet and C2C12 myotubes co-treated with D-gal and PA in this study. Our in vivo data showed that sesamol activated AKT/mTOR/FoxO1 signal pathway, and then upregulated p-p70S6K and p-4EBP1 to promote myoprotein synthesis, and downregulated Atrogin-1 and MuRF1 to inhibit myoprotein degradation, thus ameliorating sarcopenia related to aging and obesity. Furthermore, our in vitro results confirmed the protective effect and aforementioned mechanisms of sesamol on sarcopenia. Collectively, sesamol could alleviate sarcopenia associated with aging and obesity via activating the AKT/mTOR/FoxO1 signal pathway. Our findings highlight the therapeutic potentials of sesamol for aging and obesity-related metabolic muscular complications.

Indexed as

AgingBenzodioxolesForkhead Box Protein O1ObesityPhenolsSarcopeniaSignal TransductionAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLMice, ObeseMuscle ProteinsProto-Oncogene Proteins c-aktSKP Cullin F-Box Protein LigasesBenzodioxolesForkhead Box Protein O1Foxo1 protein, mousemTOR protein, mouseMuscle ProteinsPhenolsProto-Oncogene Proteins c-aktsesamolSKP Cullin F-Box Protein LigasesTOR Serine-Threonine KinasesTrim63 protein, mouseTripartite Motif ProteinsUbiquitin-Protein LigasesAgingAKT/mTOR/FoxO1 signal pathwayObesitySarcopeniaSesamol

Identifiers

PMID38879661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.