Molecularly imprinted polymer-based extended-gate field-effect transistor chemosensors for selective determination of antiepileptic drug.

Jin Chul Yang, Nari Shin, Seok Jin Lim, Chae Hwan Cho, Deepshikha Hazarika, Jong Pil Park, Jinyoung Park

Abstract read

In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

First Dimension Trap-and-Elute Combined with Second Dimension Reversed-Phase Liquid Chromatography Separation Using a Two-Dimensional-Liquid Chromatography-Tandem Mass Spectrometry System for Sensitive Quantification of Human Insulin and Six Insulin Analogs in Plasma: Improved Chromatographic Resolution and Stability Testing.Journal of separation science · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jin Chul YangDepartment of Polymer Science & Engineering, Kyungpook National University, 80 Daehak-Ro, Daegu, 41566, Republic of Korea.

Nari ShinDepartment of Polymer Science & Engineering, Kyungpook National University, 80 Daehak-Ro, Daegu, 41566, Republic of Korea.

Seok Jin LimDepartment of Polymer Science & Engineering, Kyungpook National University, 80 Daehak-Ro, Daegu, 41566, Republic of Korea.

Chae Hwan ChoDepartment of Food Science and Technology, and GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546, Republic of Korea.

Deepshikha HazarikaDepartment of Polymer Science & Engineering, Kyungpook National University, 80 Daehak-Ro, Daegu, 41566, Republic of Korea.

Jong Pil ParkDepartment of Food Science and Technology, and GreenTech-based Food Safety Research Group, BK21 Four, Chung-Ang University, Anseong, 17546, Republic of Korea. jppark@cau.ac.kr.

Jinyoung ParkDepartment of Polymer Science & Engineering, Kyungpook National University, 80 Daehak-Ro, Daegu, 41566, Republic of Korea. jinpark@knu.ac.kr.ORCID http://orcid.org/0000-0003-0261-7605

Funding

National Research Foundation of Korea NRF-2020R1I1A3070148National Research Foundation of Korea RS-2023-00240220

6 · The paper itself

Abstract

Ultrathin molecularly imprinted polymer (MIP) films were deposited on the surfaces of ZnO nanorods (ZNRs) and nanosheets (ZNSs) by electropolymerization to afford extended-gate field-effect transistor sensors for detecting phenytoin (PHT) in plasma. Molecular imprinting efficiency was optimized by controlling the contents of functional monomers and the template in the precursor solution. PHT sensing was performed in plasma solutions with various concentrations by monitoring the drain current as a function of drain voltage under an applied gate voltage of 1.5 V. The reliability and reproducibility of the fabricated sensors were evaluated through a solution treatment process for complete PHT removal and PHT adsorption-removal cycling, while selectivity was examined by analyzing responses to chemicals with structures analogous to that of PHT. Compared with the ZNS/extracted-MIP sensor and sensors with non-imprinted polymer (NIP) films, the ZNR/extracted-MIP sensor showed superior responses to PHT-containing plasma due to selective PHT adsorption, achieving an imprinting factor of 4.23, detection limit of 12.9 ng/mL, quantitation limit of 53.0 ng/mL, and selectivity coefficients of 3-4 (against tramadol) and ~ 5 (against diphenhydramine). Therefore, we believe that the MIP-based ZNR sensing platform is promising for the practical detection of PHT and other drugs and evaluation of their proper dosages.

Indexed as

AnticonvulsantsLimit of DetectionMolecularly Imprinted PolymersPhenytoinTransistors, ElectronicZinc OxideAdsorptionHumansMolecular ImprintingNanotubesPolymersReproducibility of ResultsAnticonvulsantsMolecularly Imprinted PolymersPhenytoinPolymersZinc OxideAntiepileptic drugDrain currentExtended-gate field-effect transistorImprinting factorMolecular imprintingZinc oxide pattern

Identifiers

PMID38879615

DOI10.1007/s00604-024-06487-x

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.