ArticleNPJ Parkinson's disease2024
Subthalamic nucleus input-output dynamics are correlated with Parkinson's burden and treatment efficacy.
Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- Association between aperiodic activity and impulsivity in individuals with methamphetamine use disorder.Psychopharmacology · 2026Article
- Device-embedded accelerometry complements neural signals for tracking parkinsonian motor states.bioRxiv : the preprint server for biology · 2026Article
- Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state.Brain : a journal of neurology · 2026Article
- Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Temporal Dynamics of Microlesion Effects in Subthalamic Local Field Potentials.Neurologia medico-chirurgica · 2026Article
- A meta-analysis of periodic and aperiodic electrophysiological features in Parkinson's disease.Brain communications · 2026Review
- Beyond beta rhythms: subthalamic aperiodic broadband power scales with Parkinson's disease severity-a cross-sectional multicentre study.EBioMedicine · 2025Article
- Adaptive proximity to criticality underlies amplification of ultra-slow fluctuations during free recall.PLoS computational biology · 2025Article
- Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson's disease: a multisite functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
The subthalamic nucleus (STN) is pivotal in basal ganglia function in health and disease. Micro-electrode recordings of >25,000 recording sites from 146 Parkinson's patients undergoing deep brain stimulation (DBS) allowed differentiation between subthalamic input, represented by local field potential (LFP), and output, reflected in spike discharge rate (SPK). As with many natural systems, STN neuronal activity exhibits power-law dynamics characterized by the exponent α. We, therefore, dissected STN data into aperiodic and periodic components using the Fitting Oscillations & One Over F (FOOOF) tool. STN LFP showed significantly higher aperiodic exponents than SPK. Additionally, SPK beta oscillations demonstrated a downward frequency shift compared to LFP. Finally, the STN aperiodic and spiking parameters explained a significant fraction of the variance of the burden and treatment efficacy of Parkinson's disease. The unique STN input-output dynamics may clarify its role in Parkinson's physiology and can be utilized in closed-loop DBS therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.