Evidence map›Paper›PMID 38879468›Full record

ArticleBMC neurology2024

MiR-18a affects hypoxia induced glucose metabolism transition in HT22 hippocampal neuronal cell line through the Hif1a gene.

Chuncheng Liu, Gehui Liu, Xinyang Zuo, Donghui Qu, Yefeng Sun, Linan Liu, Xiujuan Zhao, Jun Li, Lu Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chuncheng LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Gehui LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Xinyang ZuoSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Donghui QuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Yefeng SunSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Linan LiuSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Xiujuan ZhaoSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Jun LiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Lu CaiSchool of Life Science and Technology, Inner Mongolia University of Science and Technology, Baotou, 014010, China. nmcailu@163.com.

Funding

the Fundamental Research Funds for Inner Mongolia University of Science & Technology 2023RCTD019the Fundamental Research Funds for Inner Mongolia University of Science & Technology 2023YXXS027the Fundamental Research Funds for Inner Mongolia University of Science & Technology Nonethe National Natural Science Foundation of China 62071259
6 · The paper itself

Abstract

Hypoxia can cause a variety of diseases, including ischemic stroke and neurodegenerative diseases. Within a certain range of partial pressure of oxygen, cells can respond to changes in oxygen. Changes in oxygen concentration beyond a threshold will cause damage or even necrosis of tissues and organs, especially for the central nervous system. Therefore, it is very important to find appropriate measures to alleviate damage. MiRNAs can participate in the regulation of hypoxic responses in various types of cells. MiRNAs are involved in regulating hypoxic responses in many types of tissues by activating the hypoxia-inducible factor (HIF) to affect angiogenesis, glycolysis and other biological processes. By analyzing differentially expressed miRNAs in hypoxia and hypoxia-related studies, as well as the HT22 neuronal cell line under hypoxic stress, we found that the expression of miR-18a was changed in these models. MiR-18a could regulate glucose metabolism in HT22 cells under hypoxic stress by directly regulating the 3'UTR of the Hif1a gene. As a small molecule, miRNAs are easy to be designed into small nucleic acid drugs, so this study can provide a theoretical basis for the research and treatment of nervous system diseases caused by hypoxia.

Indexed as

GlucoseHippocampusHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsNeuronsAnimalsCell HypoxiaCell LineHumansMiceGlucoseHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsGlucose metabolismHif1aHypoxiamiR-18aNeuronal

Identifiers

PMID38879468
PMCPMC11179257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.