Evidence map›Paper›PMID 38879462›Full record

ArticleJournal of the American Heart Association2024

Level of Perivascular Inflammation Is Significantly Lower Around the Left Internal Mammary Artery Than Around Native Coronary Arteries.

Haruhito Yuki, Thoralf M Sundt, Takayuki Niida, Keishi Suzuki, Daisuke Kinoshita, Daichi Fujimoto, Damini Dey, Hang Lee, Iris McNulty, Toru Naganuma and 4 more

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04523194 (Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04523194 active not recruitingnot on this map

Massachusetts General Hospital and Tsuchiura Kyodo General Hospital Coronary Imaging Collaboration

TypeobservationalSponsorMassachusetts General HospitalRan2020 to 2027Enrolled1,000ConditionsAtherosclerosisArmsOptical Coherence Tomography (OCT) and Computed Tomography Angiography (CTA)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haruhito YukiCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0000-0002-2284-7611
Thoralf M SundtCardiac Surgery Division, Department of Surgery Massachusetts General Hospital, Harvard Medical School Boston MA.
Takayuki NiidaCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0000-0003-1586-4971
Keishi SuzukiCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0009-0001-5543-2420
Daisuke KinoshitaCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0000-0001-5571-5079
Daichi FujimotoCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0000-0001-5455-674X
Damini DeyBiomedical Imaging Research Institute, Cedars-Sinai Medical Center Los Angeles CA.ORCID 0000-0003-2236-6970
Hang LeeBiostatistics Center Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0000-0002-3498-236X
Iris McNultyCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0009-0009-3962-8034
Toru NaganumaInterventional Cardiology Unit New Tokyo Hospital Chiba Japan.
Sunao NakamuraInterventional Cardiology Unit New Tokyo Hospital Chiba Japan.ORCID 0000-0002-0651-0090
Eisuke UsuiDepartment of Cardiology Tsuchiura Kyodo General Hospital Tsuchiura Japan.ORCID 0000-0002-5454-3743
Tsunekazu KakutaDepartment of Cardiology Tsuchiura Kyodo General Hospital Tsuchiura Japan.ORCID 0000-0002-4004-5292
Ik-Kyung JangCardiology Division Massachusetts General Hospital, Harvard Medical School Boston MA.ORCID 0000-0002-5796-3006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe left internal mammary artery (LIMA) is protected from developing atherosclerosis. Perivascular inflammation, which is closely associated with atherosclerosis, can be measured by perivascular adipose tissue attenuation on computed tomography angiography. Whether the absence of atherosclerosis in LIMA is related to the lower level of perivascular inflammation is unknown. This study was performed to compare the level of perivascular inflammation between LIMA in situ and native coronary arteries in patients with coronary artery disease. METHODS AND

resultsA total of 573 patients who underwent both computed tomography angiography and optical coherence tomography imaging were included. The level of perivascular adipose tissue attenuation between LIMA in situ and coronary arteries was compared. Perivascular adipose tissue attenuation around LIMA in situ was significantly lower around the 3 coronary arteries (-82.9 [-87.3 to -78.0] versus -70.8 [-75.9 to -65.9];

conclusionsThe current study demonstrated that perivascular adipose tissue attenuation was significantly lower around LIMA in situ than around native coronary arteries. The lower level of perivascular inflammation may be related to the low prevalence of atherosclerosis in LIMA. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT04523194.

Indexed as

Adipose TissueComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsMammary ArteriesTomography, Optical CoherenceAgedFemaleHumansInflammationMaleMiddle AgedRetrospective Studiescomputed tomography angiographyleft internal mammary arteryoptical coherence tomographyperivascular inflammation

Identifiers

PMID38879462
PMCPMC11255748

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.