ReviewJournal of the American Heart Association2024
Role of Antitroponin Antibodies and Macrotroponin in the Clinical Interpretation of Cardiac Troponin.
Review in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07726420 (HEARTBEAT-TROP. Testing of Polyethylene Glycol Precipitation to Unmask Macrotroponin in Acute Coronary Syndrome and Marathon Runners.), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
HEARTBEAT-TROP. Testing of Polyethylene Glycol Precipitation to Unmask Macrotroponin in Acute Coronary Syndrome and Marathon Runners.
Who cites it
18 citing papers in PubMed.
- Multifunctional cardiac tropin I sensing using MWCNTs-COOH/PoPD composites for integrated warning, screening and protection assessment of traditional Chinese medicine-induced cardiotoxicity.Mikrochimica acta · 2026Article
- A case report of falsely elevated high-sensitivity cardiac troponin I due to macro-troponin I.Practical laboratory medicine · 2026Article
- Diagnostic validation of a novel high-sensitivity cardiac troponin T assay.European heart journal. Acute cardiovascular care · 2026Article
- Handling persistent cardiac troponin elevation in asymptomatic athletes: The role of macrocomplexes.American heart journal plus : cardiology research and practice · 2026Article
- Sex matters: mechanistic insights into sex-driven patterns of autoimmunity and implications for pharmacotherapy.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- False-positive troponin in a professional cyclist: a case report on avoiding misdiagnosis and unnecessary restrictions.European heart journal. Case reports · 2026Article
- Clinical Impact of Macrotroponin on Immunometric Troponin Assays: A Cross-Analytical Case Evaluation.International journal of molecular sciences · 2026Article
- Article
- Disproportionate Elevated Troponin T Without Clinical Ischemia: A Diagnostic Challenge in the Emergency Department.Case reports in medicine · 2026Article
- False-Positive Cardiac Troponin Elevations in Skeletal Muscle Disease: Clinical Relevance, Mechanisms, and Laboratory Approaches.Physiological research · 2025Review
- False Troponin Elevation in Pediatric Patients: A Long-Term Biochemical Conundrum Without Cardiac Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Interfering heterophile antibodies as the cause of persistently falsely elevated high-sensitivity troponin I on Alinity i: a case report.Biochemia medica · 2025Article
- New and Emerging Biomarkers in Chronic Kidney Disease.Biomedicines · 2025Review
- Beyond monoclonal antibodies: constraints and the case for alternative PD-1/PD-L1-targeting formats.Frontiers in immunology · 2025Review
- Cardiac involvement in female elite athletes with carrier status of Duchenne muscular dystrophy.Frontiers in cardiovascular medicine · 2025Review
- Overview of immune checkpoint inhibitor associated myocarditis mechanisms diagnostics and treatment.Frontiers in immunology · 2025Review
- Cardiac Troponin Levels in Patients with Chronic Kidney Disease: "Markers of High Risk or Just Noise''?Diagnostics (Basel, Switzerland) · 2024Review
- High sensitivity troponins and mortality in the population with metabolic dysfunction-associated steatotic liver disease.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac troponin is extensively used as a biomarker in modern medicine due to its diagnostic capability for myocardial injury, as well as its predictive and prognostic value for cardiac diseases. However, heterophile antibodies, antitroponin antibodies, and macrotroponin complexes can be observed both in seemingly healthy individuals and patients with cardiac diseases, potentially leading to false positive or disproportionate elevation of cTn (cardiac troponin) assay results and introducing discrepancies in clinical interpretations with impact on medical management. In this review article, we describe the possible mechanisms of cTn release and the sources of variations in the assessment of circulating cTn levels. We also explore the pathophysiological mechanisms underlying antitroponin antibody development and discuss the influence exerted by macrotroponin complexes on the results of immunoassays. Additionally, we explore approaches to detect these complexes by presenting various clinical scenarios encountered in routine clinical practice. Finally, unsolved questions about the development, prevalence, and clinical significance of cardiac autoantibodies are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.