Evidence map›Paper›PMID 38879355›Full record

ArticleAmerican journal of surgery2024

Trends in thyroid function following radiofrequency ablation of benign, nonfunctioning thyroid nodules: A single institution review.

Stephanie J Chan, Madison C Betcher, Eric J Kuo, Catherine M McManus, James A Lee, Jennifer H Kuo

Abstract read
In one paragraph

Article in American journal of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie J ChanDivision of GI/Endocrine Surgery, Columbia University, New York, NY, USA.
Madison C BetcherDivision of GI/Endocrine Surgery, Columbia University, New York, NY, USA.
Eric J KuoDivision of GI/Endocrine Surgery, Columbia University, New York, NY, USA.
Catherine M McManusDivision of GI/Endocrine Surgery, Columbia University, New York, NY, USA.
James A LeeDivision of GI/Endocrine Surgery, Columbia University, New York, NY, USA.
Jennifer H KuoDivision of GI/Endocrine Surgery, Columbia University, New York, NY, USA. Electronic address: jhk2029@cumc.columbia.edu.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
NCATS NIH HHS UL1 TR001450NCATS NIH HHS UL1 TR001873
6 · The paper itself

Abstract

backgroundRadiofrequency ablation (RFA) effectively reduces volume and improves symptoms of benign, non-functioning thyroid nodules (NFTNs). Given RFA's unclear impact on thyroid function, we examined post-RFA trends in thyroid hormones and antibodies.

methodsA retrospective cross-sectional analysis was conducted of patients treated at Columbia University with RFA for benign NFTNs between August 2019 and July 2023. Thyroid function tests were recorded pre-RFA and repeated 3, 6, and 12 months post-RFA.

resultsWe analyzed 185 patients with 243 benign NFTNs who underwent RFA. Volume reduction ratio increased post-RFA. Mean TSH increased to 2.4 mlU/L (p ​= ​0.005) at 3 months post-RFA and decreased to 1.8 mlU/L (p ​= ​0.551) by 12 months post-RFA. Tg and TPO antibody levels peaked at 6 months post-RFA (103.1 IU/mL, p ​= ​0.868 and 66.6 IU/mL, p ​= ​0.523, respectively).

conclusionsWith expected volume reduction post-RFA, we observed transient relative hypothyroidism as well as transient increases in thyroid antibodies, with normalization of these changes within 12 months.

Indexed as

Radiofrequency AblationThyroid Function TestsThyroid NoduleAdultAgedCross-Sectional StudiesFemaleHumansHypothyroidismMaleMiddle AgedRetrospective StudiesThyroid GlandRadiofrequency ablationThyroid function testsThyroid nodules

Identifiers

PMID38879355
PMCPMC11438571

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.