ArticleThe American journal of pathology1985
Leu-M1--a marker for Reed-Sternberg cells in Hodgkin's disease. An immunoperoxidase study of paraffin-embedded tissues.
Article in The American journal of pathology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 152 citations in OpenAlex.
- FVIIIra, CD15, and tryptase performance in the diagnosis of skin stab wound vitality in forensic pathology.International journal of legal medicine · 2013Article
- Oral lesions and lymphoproliferative disorders.Journal of oncology · 2010Article
- Frequency of acute asymptomatic myocardial infarction and an estimate of infarct age in cases of abrupt sudden death observed in a forensic autopsy material.Journal of cellular and molecular medicine · 2008Article
- Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?The American journal of pathology · 1997Article
- Leu-M1 immunoreactivity and phaeochromocytoma.Journal of clinical pathology · 1997Article
- Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours. Preferential reactivity with malignant tumours.Virchows Archiv : an international journal of pathology · 1996Article
- Increased interleukin-6 (IL-6) production in a young child with clinical and pathologic features of multicentric Castleman's disease.Journal of clinical immunology · 1994Article
- bcl-2 rearrangement in Hodgkin's disease. Results of polymerase chain reaction, flow cytometry, and sequencing on formalin-fixed, paraffin-embedded tissue.The American journal of pathology · 1993Article
- Expression of CD15 in tumours of the nervous system.The Histochemical journal · 1992Article
- Bauhinia purpurea--a new paraffin section marker for Reed-Sternberg cells of Hodgkin's disease. A comparison with Leu-M1 (CD15), LN2 (CD74), peanut agglutinin, and Ber-H2 (CD30).The American journal of pathology · 1992Article
- Immunohistochemical localization of granzyme B antigen in cytotoxic cells in human tissues.The American journal of pathology · 1991Article
- Computer assisted selection and assessment of antibodies in the diagnosis of lymphomas.Journal of clinical pathology · 1990Article
- Hairy cell leukemia-associated antigen LeuM5 (CD11c) is preferentially expressed by benign activated and neoplastic CD8 T cells.The American journal of pathology · 1990Article
- Monomorphic lymphomas arising in patients with Hodgkin's disease. Correlation of morphologic, immunophenotypic, and molecular genetic findings in 12 cases.The American journal of pathology · 1990Article
- Comparative quality assessment in immunocytochemistry: pilot study of CD15 staining in paraffin wax embedded tissue in Hodgkin's disease.Journal of clinical pathology · 1989Article
- Formalin-resistant leukocyte surface antigens in the diagnosis of cutaneous malignant lymphomas.The American journal of pathology · 1989Article
- Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia.The American journal of pathology · 1989Review
- Hodgkin's disease, lymphocyte predominance type, nodular--further evidence for a B cell derivation. L & H variants of Reed-Sternberg cells express L26, a pan B cell marker.The American journal of pathology · 1988Article
- Differentiation of adenocarcinoma of the lung from mesothelioma. Periodic acid-Schiff, monoclonal antibodies B72.3, and Leu M1.The American journal of pathology · 1988Article
- Transformation of cutaneous T cell lymphoma to large cell lymphoma. A clinicopathologic and immunologic study.The American journal of pathology · 1988Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Monoclonal antibody to Leu-M1, a granulocyte-related differentiation antigen, represents a highly effective reagent for detection of diagnostic Reed-Sternberg (R-S) cells and variants in paraffin-embedded tissues of Hodgkin's disease. In 69 of 73 cases of Hodgkin's disease (41 nodular sclerosis, 25 mixed cellularity, 4 lymphocyte predominance, and 3 lymphocyte depletion types), R-S cells were strongly immunoreactive for Leu-M1. Four cases of lymphocyte predominance Hodgkin's disease (nodular) were uniformly nonreactive for Leu-M1. In most of the positive cases (57/69, 83%), the majority (60-90%) of R-S cells and variants exhibited immunoreactivity for Leu-M1. A characteristic staining pattern included granular and/or vesicular cytoplasmic immunoreactivity, often with a prominent globular paranuclear reaction product, and membrane staining with highly irregular cytoplasmic borders. Evaluation of B-cell (37 specimens), T-cell (20 specimens), and true histiocytic (3 specimens) neoplasms and a case of mastocytosis revealed immunoreactivity for Leu-M1 only in 1 B-cell and 4 T-cell malignancies. The staining patterns in these cases, however, clearly differed from that observed for R-S cells. Studies of nonneoplastic lymphoid tissues (38 total) demonstrated that lymphoid cells were typically nonreactive; histiocytes revealed variable reactivity for Leu-M1. Occasional histiocytes of the sinusoidal network of lymph nodes, particularly in toxoplasmic lymphadenitis, exhibited a staining pattern (membranous/cytoplasmic/paranuclear) similar to that observed for R-S cells. Leu-M1 represents a potentially helpful diagnostic discriminant in the assessment of Hodgkin's disease and its distinction from non-Hodgkin's lymphomas and other lymphoid proliferations.
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Identifiers
3887932PMC1887896W158879157What OpenQuestion holds
Registered trials
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