Evidence map›Paper›PMID 38878815›Full record

ArticleNeuroscience2025

Regulation by Presynaptic NMDA Receptors of Non-Linear Postsynaptic Summation of the Cortical Input to CA1 Pyramidal Neurons.

Eric W Buss, Yu-Qiu Jiang, Bina Santoro, David H Brann, Daniel A Nicholson, Steven A Siegelbaum, Qian Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eric W BussDepartment of Neuroscience, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Yu-Qiu JiangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Bina SantoroDepartment of Neuroscience, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
David H BrannDepartment of Neuroscience, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Daniel A NicholsonDepartment of Neuroscience, Rush University Medical Center, Chicago, IL, USA.
Steven A SiegelbaumDepartment of Neuroscience, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: sas8@columbia.edu.
Qian SunDepartment of Neuroscience, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: qxs111@case.edu.

Funding

Genetic targeting of hippocampal CA2 pyramidal neuronsR01MH104602 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN A SIEGELBAUM · 2014 to 2026
$5.9M
The role of the hippocampal CA2 region in neuropsychiatric diseaseR01MH106629 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIEGELBAUM, STEVEN A · 2016 to 2020
$2.1M
Long-range GABAergic inhibition coordinates hippocampal-subcortical circuit activity in memory formationR01MH130367 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI Qian Sun · 2023 to 2026
$2.0M
The role of subcortical inputs to the hippocampal CA3 region in fear memoryR01MH129294 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI Qian Sun · 2023 to 2026
$1.6M
Dorsoventral functional divergence of the hippocampal CA3 circuitK01MH117444 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SUN, QIAN · 2018 to 2021
$492k
NIMH NIH HHS K01 MH117444NIMH NIH HHS R01 MH104602NIMH NIH HHS R01 MH106629NIMH NIH HHS R01 MH129294NIMH NIH HHS R01 MH130367
6 · The paper itself

Abstract

Entorhinal cortex (EC) LIII and LII glutamatergic neurons make monosynaptic connections onto distal apical dendrites of hippocampal CA1 and CA2 pyramidal neurons (PNs), respectively, through perforant path (PP) projections. We previously reported that a brief train of PP stimuli evokes strong supralinear temporal summation of excitatory postsynaptic potentials (EPSPs) in CA1 PNs that requires NMDAR activation, with relatively little summation in CA2 PNs in mice of either sex. Here we provide evidence from combined immunogold electron microscopy, cell-type specific genetic deletion and pharmacology that the NMDARs required for supralinear temporal summation of the CA1 PP EPSP are presynaptic, located in the PP terminals. Moreover, we found that the number of NMDARs in PP terminals innervating CA1 PNs is significantly greater than that found in PP terminals innervating CA2 PNs, providing a potential explanation for the difference in temporal summation in these two classes of hippocampal PNs.

Indexed as

CA1 Region, HippocampalExcitatory Postsynaptic PotentialsPresynaptic TerminalsPyramidal CellsReceptors, N-Methyl-D-AspartateAnimalsEntorhinal CortexFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPerforant PathwayReceptors, N-Methyl-D-AspartateCA1CA2hippocampusNMDA receptorpostsynapticpresynaptic

Identifiers

PMID38878815
PMCPMC11638401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.