Evidence map›Paper›PMID 38878680›Full record

ArticleJournal of inorganic biochemistry2024

Heme pocket modulates protein conformation and diguanylate cyclase activity of a tetrameric globin coupled sensor.

Jacob R Potter, Shannon Rivera, Paul G Young, Dayna C Patterson, Kevin E Namitz, Neela Yennawar, James R Kincaid, Yilin Liu, Emily E Weinert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob R PotterDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
Shannon RiveraDepartment of Chemistry, Emory University, Atlanta, GA 30322, USA.
Paul G YoungDepartment of Chemistry, Emory University, Atlanta, GA 30322, USA.
Dayna C PattersonDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
Kevin E NamitzDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802, USA; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Neela YennawarThe Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
James R KincaidDepartment of Chemistry, Marquette University, Milwaukee, WI 53233, USA. Electronic address: james.kincaid@marquette.edu.
Yilin LiuDepartment of Chemistry, Marquette University, Milwaukee, WI 53233, USA; Department of Chemistry, University of Akron, Akron, OH 44325, USA. Electronic address: yliu1@uakron.edu.
Emily E WeinertDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA. Electronic address: emily.weinert@psu.edu.

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
X-ray instrumentation upgrade for single crystal diffraction and solution small angle scatteringS10OD028589 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2020 to 2020
$600k
Beckman Optima Multiwavelength Analytical UltracentrifugeS10OD032215 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2022 to 2022
$512k
Macromolecular X-Ray Crystallography InstrumentS10RR023439 · NCRR · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2007 to 2007
$500k
Wyatt SEC-MALS systemS10OD030490 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI YENNAWAR, NEELA H. · 2021 to 2021
$273k
NCRR NIH HHS S10 RR023439NIGMS NIH HHS P30 GM124166NIH HHS S10 OD028589NIH HHS S10 OD030490NIH HHS S10 OD032215
6 · The paper itself

Abstract

Bacteria use the second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) to control biofilm formation and other key phenotypes in response to environmental signals. Changes in oxygen levels can alter c-di-GMP signaling through a family of proteins termed globin coupled sensors (GCS) that contain diguanylate cyclase domains. Previous studies have found that GCS diguanylate cyclase activity is controlled by ligand binding to the heme within the globin domain, with oxygen binding resulting in the greatest increase in catalytic activity. Herein, we present evidence that heme-edge residues control O

Indexed as

Bacterial ProteinsHemePectobacterium carotovorumPhosphorus-Oxygen LyasesCyclic GMPEscherichia coli ProteinsOxygenProtein ConformationBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsHemeOxygenPhosphorus-Oxygen LyasesDiguanylate cyclaseGlobinHemeOxygen sensingResonance RamanSmall angle X-ray scattering

Identifiers

PMID38878680
PMCPMC12746716

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.