Evidence map›Paper›PMID 38878585›Full record

ArticlePatient education and counseling2024

Sticking to the script: Breast cancer patients' decision making regarding oral endocrine therapy.

Stephanie B Wheeler, Megan C Roberts, Austin R Waters, Diane Bloom, Jeffrey Peppercorn, Carol Golin, Katherine E Reeder-Hayes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Patient education and counseling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie B WheelerDepartment of Health Policy and Management, University of North Carolina at Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA. Electronic address: stephanie_wheeler@unc.edu.
Megan C RobertsDivision of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, USA.
Austin R WatersDepartment of Health Policy and Management, University of North Carolina at Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA.
Diane BloomDepartment of Health Policy and Management, University of North Carolina at Chapel Hill, NC, USA.
Jeffrey PeppercornDana Farber Cancer Center, Harvard University, MA, USA.
Carol GolinDepartment of Health Behavior, University of North Carolina at Chapel Hill, NC, USA.
Katherine E Reeder-HayesLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA; Division of Hematology and Oncology, University of North Carolina at Chapel Hill, NC, USA.

Funding

Cancer Care Quality Training ProgramT32CA116339 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ETHAN M. BASCH, Stephanie Brooke Wheeler · 2018 to 2026
$3.0M
Optimizing Endocrine Therapy Adherence through Motivational Interviewing and Text InterventionsR01CA237357 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REEDER-HAYES, KATHERINE E, WHEELER, STEPHANIE BROOKE · 2019 to 2023
$3.0M
NCI NIH HHS R01 CA237357NCI NIH HHS T32 CA116339
6 · The paper itself

Abstract

objectivesWe sought to understand why some women with early-stage breast cancer decide to forgo or discontinue endocrine therapy (ET), and to identify factors that might lead to greater acceptance of, and long-term adherence to, this treatment.

methodsWe conducted in-depth interviews with N = 53 stage I-III HR+ women who were either non-initiators of ET, initiators who discontinued or initiators who continued with variable daily patterns of adherence. An inductive content analysis was performed to explore the decision-making process of women prescribed ET.

resultsQualitative analyses revealed 55 themes that drove complex decision making. The initiators generally trusted their physicians and did little research before starting the medication. Non-initiators were more suspicious of the medical system, believing that ET presented more risks than benefits. Most discontinuers stopped ET because of side effects. Both non-initiators and discontinuers indicated that push-back from their physicians could have changed their decision. Stories and social support were important in decision making.

conclusionsAlthough ET can significantly reduce the risk of breast cancer recurrence, substantial barriers prevent many women from initiating or continuing it. PRACTICE IMPLICATIONS: Physicians have powerful influence over patients' decisions to initiate ET and can be important levers for motivating patients to persist.

Indexed as

Antineoplastic Agents, HormonalBreast NeoplasmsDecision MakingInterviews as TopicPhysician-Patient RelationsQualitative ResearchAdministration, OralAdultAgedFemaleHumansMedication AdherenceMiddle AgedSocial SupportAntineoplastic Agents, HormonalBreast cancerEndocrine therapyOncologyQualitative interviews

Identifiers

PMID38878585
PMCPMC12983416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.